ArticleBiophysical journal2001
Ultraweak sugar-sugar interactions for transient cell adhesion.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 74 citations in OpenAlex.
- Insights into spheroids formation in cellulose nanofibrils and Matrigel hydrogels using AFM-based techniques.Materials today. Bio · 2024Article
- Measuring pico-Newton Forces with Lipid Anchors as Force Sensors in Molecular Dynamics Simulations.The journal of physical chemistry. B · 2023Article
- Glycan-to-Glycan Binding: Molecular Recognition through Polyvalent Interactions Mediates Specific Cell Adhesion.Molecules (Basel, Switzerland) · 2021Review
- Interplay ofFrontiers in molecular biosciences · 2021Article
- Quantified forces between HepG2 hepatocarcinoma and WA07 pluripotent stem cells with natural biomaterials correlate with in vitro cell behavior.Scientific reports · 2019Article
- Size, Kinetics, and Free Energy of Clusters Formed by Ultraweak Carbohydrate-Carbohydrate Bonds.Biophysical journal · 2016Article
- Equilibrium-fluctuation-analysis of single liposome binding events reveals how cholesterol and Ca2+ modulate glycosphingolipid trans-interactions.Scientific reports · 2013Article
- Cellular interaction through LewisX cluster: theoretical studies.Journal of molecular modeling · 2008Article
- First synthesis of two deoxy Lewis(x) pentaosyl glycosphingolipids.Glycoconjugate journal · 2008Article
- Structure, surface interactions, and compressibility of bacterial S-layers through scanning force microscopy and the surface force apparatus.Biophysical journal · 2006Article
- SP-A binds alpha1-antitrypsin in vitro and reduces the association rate constant for neutrophil elastase.Respiratory research · 2005Article
- Molecular dynamics simulations and 2H NMR study of the GalCer/DPPG lipid bilayer.Biophysical journal · 2005Article
- Specific and non specific interactions involving Le( X ) determinant quantified by lipid vesicle micromanipulation.Glycoconjugate journal · 2004Article
- Understanding carbohydrate-carbohydrate interactions by means of glyconanotechnology.Glycoconjugate journal · 2004Review
- A glycosynapse in myelin?Glycoconjugate journal · 2004Review
- Studies of the carbohydrate-carbohydrate interaction between lactose and GM(3) using Langmuir monolayers and glycolipid micelles.Glycoconjugate journal · 2004Article
- Carbohydrate antigens expressed on stem cells and early embryonic cells.Glycoconjugate journal · 2004Review
- Lactosylceramide: effect of acyl chain structure on phase behavior and molecular packing.Biophysical journal · 2002Article
- Structure of hydroxylated galactocerebrosides from myelin at the air-water interface.Biophysical journal · 2002Article
- Synthesis of a highly hydrophobic dimeric Lewis X containing glycolipid: a model for the study of homotypic carbohydrate--carbohydrate interaction.Glycoconjugate journal · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbohydrate-carbohydrate interactions are rarely considered in biologically relevant situations such as cell recognition and adhesion. One Ca(2+)-mediated homotypic interaction between two Lewis(x) determinants (Le(x)) has been proposed to drive cell adhesion in murine embryogenesis. Here, we confirm the existence of this specific interaction by reporting the first direct quantitative measurements in an environment akin to that provided by membranes. The adhesion between giant vesicles functionalized with Le(x) was obtained by micropipette aspiration and contact angle measurements. This interaction is below the thermal energy, and cell-cell adhesion will require a large number of molecules, as illustrated by the Le(x) concentration peak observed at the cell membranes during the morula stage of the embryo. This adhesion is ultralow and therefore difficult to measure. Such small interactions explain why the concept of specific interactions between carbohydrates is often neglected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.