ArticleBiophysical journal2001
Voltage-dependent membrane capacitance in rat pituitary nerve terminals due to gating currents.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
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- Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point.Hearing research · 2022Article
- State dependent effects on the frequency response of prestin's real and imaginary components of nonlinear capacitance.Scientific reports · 2021Article
- An Electrophysiological Approach to Measure Changes in the Membrane Surface Potential in Real Time.Biophysical journal · 2020Article
- The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Tissue-specific dynamin-1 deletion at the calyx of Held decreases short-term depression through a mechanism distinct from vesicle resupply.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The capacitance and electromechanical coupling of lipid membranes close to transitions: the effect of electrostriction.Biophysical journal · 2012Article
- Critical roles of voltage-dependent sodium channels in the process of synaptogenesis during the postnatal cortical development of rats.Cellular and molecular neurobiology · 2009Article
- A combined patch-clamp and electrorotation study of the voltage- and frequency-dependent membrane capacitance caused by structurally dissimilar lipophilic anions.The Journal of membrane biology · 2008Article
- Voltage-dependent capacitance of human embryonic kidney cells.Physical review. E, Statistical, nonlinear, and soft matter physics · 2006Article
- A large pool of releasable vesicles in a cortical glutamatergic synapse.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
We investigated the voltage dependence of membrane capacitance of pituitary nerve terminals in the whole-terminal patch-clamp configuration using a lock-in amplifier. Under conditions where secretion was abolished and voltage-gated channels were blocked or completely inactivated, changes in membrane potential still produced capacitance changes. In terminals with significant sodium currents, the membrane capacitance showed a bell-shaped dependence on membrane potential with a peak at approximately -40 mV as expected for sodium channel gating currents. The voltage-dependent part of the capacitance showed a strong correlation with the amplitude of voltage-gated Na+ currents and was markedly reduced by dibucaine, which blocks sodium channel current and gating charge movement. The frequency dependence of the voltage-dependent capacitance was consistent with sodium channel kinetics. This is the first demonstration of sodium channel gating currents in single pituitary nerve terminals. The gating currents lead to a voltage- and frequency-dependent capacitance, which can be well resolved by measurements with a lock-in amplifier. The properties of the gating currents are in excellent agreement with the properties of ionic Na+ currents of pituitary nerve terminals.
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