ArticleBiophysical journal2001
Excitation wave propagation as a possible mechanism for signal transmission in pancreatic islets of Langerhans.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 64 citations in OpenAlex.
- Ultrafast multicellular calcium imaging of calcium spikes in mouse beta cells in tissue slices.Acta physiologica (Oxford, England) · 2025Article
- Multicellular adaptation to electrophysiological perturbations analyzed by deterministic and stochastic bioelectrical models.Scientific reports · 2024Article
- Network representation of multicellular activity in pancreatic islets: Technical considerations for functional connectivity analysis.PLoS computational biology · 2024Article
- A primer on modelling pancreatic islets: from models of coupled β-cells to multicellular islet models.Islets · 2023Review
- Functional characteristics of hub and wave-initiator cells in β cell networks.Biophysical journal · 2023Article
- Multilevel synchronization of humanFrontiers in network physiology · 2023Article
- Ca2+ Oscillations, Waves, and Networks in Islets From Human Donors With and Without Type 2 Diabetes.Diabetes · 2022Article
- From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science.Frontiers in endocrinology · 2022Review
- Review
- NMDA receptor inhibition increases, synchronizes, and stabilizes the collective pancreatic beta cell activity: Insights through multilayer network analysis.PLoS computational biology · 2021Article
- Assessing Different Temporal Scales of Calcium Dynamics in Networks of Beta Cell Populations.Frontiers in physiology · 2021Article
- Adhesion Stabilized en Masse Intracellular Electrical Recordings from Multicellular Assemblies.Nano letters · 2019Article
- The role of beta cell heterogeneity in islet function and insulin release.Journal of molecular endocrinology · 2018Review
- Review
- Intrinsic islet heterogeneity and gap junction coupling determine spatiotemporal Ca²⁺ wave dynamics.Biophysical journal · 2014Article
- Cellular communication and heterogeneity in pancreatic islet insulin secretion dynamics.Trends in endocrinology and metabolism: TEM · 2014Review
- Neuropeptide Y and somatostatin inhibit insulin secretion through different mechanisms.American journal of physiology. Endocrinology and metabolism · 2013Article
- Glucose-stimulated calcium dynamics in islets of Langerhans in acute mouse pancreas tissue slices.PloS one · 2013Article
- Functional connectivity in islets of Langerhans from mouse pancreas tissue slices.PLoS computational biology · 2013Article
- Gap junction coupling and calcium waves in the pancreatic islet.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In response to glucose application, beta-cells forming pancreatic islets of Langerhans start bursting oscillations of the membrane potential and intracellular calcium concentration, inducing insulin secretion by the cells. Until recently, it has been assumed that the bursting activity of beta-cells in a single islet of Langerhans is synchronized across the whole islet due to coupling between the cells. However, time delays of several seconds in the activity of distant cells are usually observed in the islets of Langerhans, indicating that electrical/calcium wave propagation through the islets can occur. This work presents both experimental and theoretical evidence for wave propagation in the islets of Langerhans. Experiments with Fura-2 fluorescence monitoring of spatiotemporal calcium dynamics in the islets have clearly shown such wave propagation. Furthermore, numerical simulations of the model describing a cluster of electrically coupled beta-cells have supported our view that the experimentally observed calcium waves are due to electric pulses propagating through the cluster. This point of view is also supported by independent experimental results. Based on the model equations, an approximate analytical expression for the wave velocity is introduced, indicating which parameters can alter the velocity. We point to the possible role of the observed waves as signals controlling the insulin secretion inside the islets of Langerhans, in particular, in the regions that cannot be reached by any external stimuli such as high glucose concentration outside the islets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.