ArticleBiophysical journal2001
Statistical thermodynamics of membrane bending-mediated protein-protein attractions.
Article in Biophysical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Phosphatidylserine-dependent structure of synaptogyrin remodels the synaptic vesicle membrane.Nature structural & molecular biology · 2023Article
- Membrane-Mediated Interactions Between Protein Inclusions.Frontiers in molecular biosciences · 2021Review
- Transverse lipid organization dictates bending fluctuations in model plasma membranes.Nanoscale · 2020Article
- Modeling Membrane Curvature Generation due to Membrane⁻Protein Interactions.Biomolecules · 2018Review
- Membrane-mediated interaction drives mitochondrial ATPase assembly and cristae formation.The Journal of general physiology · 2018Article
- Effect of Membrane Composition on Receptor Association: Implications of Cancer Lipidomics on ErbB Receptors.The Journal of membrane biology · 2018Review
- Membrane-mediated interaction between strongly anisotropic protein scaffolds.PLoS computational biology · 2015Article
- The role of membrane-mediated interactions in the assembly and architecture of chemoreceptor lattices.PLoS computational biology · 2014Article
- Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins.Physics reports · 2014Article
- Defining the free-energy landscape of curvature-inducing proteins on membrane bilayers.Physical review. E, Statistical, nonlinear, and soft matter physics · 2014Article
- Membrane-mediated aggregation of curvature-inducing nematogens and membrane tubulation.Biophysical journal · 2013Article
- Directional interactions and cooperativity between mechanosensitive membrane proteins.Europhysics letters · 2013Article
- Membrane-mediated protein-protein interactions and connection to elastic models: a coarse-grained simulation analysis of gramicidin A association.Biophysical journal · 2013Article
- Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization.Journal of the American Chemical Society · 2011Article
- Microvesicles: mediators of extracellular communication during cancer progression.Journal of cell science · 2010Review
- Self-assembly of photosynthetic membranes.Chemphyschem : a European journal of chemical physics and physical chemistry · 2010Review
- A tail-anchored myotonic dystrophy protein kinase isoform induces perinuclear clustering of mitochondria, autophagy, and apoptosis.PloS one · 2009Article
- Calculation of free energies in fluid membranes subject to heterogeneous curvature fields.Physical review. E, Statistical, nonlinear, and soft matter physics · 2009Article
- Structure of frozen-hydrated triad junctions: a case study in motif searching inside tomograms.Journal of structural biology · 2009Article
- Stability of protein-decorated mixed lipid membranes: The interplay of lipid-lipid, lipid-protein, and protein-protein interactions.The Journal of chemical physics · 2009Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Highly wedge-shaped integral membrane proteins, or membrane-adsorbed proteins can induce long-ranged deformations. The strain in the surrounding bilayer creates relatively long-ranged forces that contribute to interactions with nearby proteins. In contrast, to direct short-ranged interactions such as van der Waal's, hydrophobic, or electrostatic interactions, both local membrane Gaussian curvature and protein ellipticity can induce forces acting at distances of up to a few times their typical radii. These forces can be attractive or repulsive, depending on the proteins' shape, height, contact angle with the bilayer, and a pre-existing local membrane curvature. Although interaction energies are not pairwise additive, for sufficiently low protein density, thermodynamic properties depend only upon pair interactions. Here, we compute pair interaction potentials and entropic contributions to the two-dimensional osmotic pressure of a collection of noncircular proteins. For flat membranes, bending rigidities of approximately 100k(B)T, moderate ellipticities, and large contact angle proteins, we find thermally averaged attractive interactions of order k(B)T. These interactions may play an important role in the intermediate stages of protein aggregation. Numerous biological processes where membrane bending-mediated interactions may be relevant are cited, and possible experiments are discussed.
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