ArticleEndocrine2000
Neuroendocrine mechanisms for reproductive senescence in the female rat: gonadotropin-releasing hormone neurons.
Article in Endocrine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
28 citing papers in PubMed, 67 citations in OpenAlex.
- In vivo growth trajectories of regional brain volumes in the Wistar rat.Neurobiology of aging · 2025Article
- Altered Electrophysiology and Transcriptome of GnRH Neurons in Middle-Aged Female Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Development of adverse outcome pathways relevant for the identification of substances having endocrine disruption properties Uterine adenocarcinoma as adverse outcome.EFSA journal. European Food Safety Authority · 2023Article
- Lactate-Dependent Cross-Talk Between Astrocyte and GnRH-I Neurons in Hypothalamus of Aged Brain: Decreased GnRH-I Transcription.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Differences in learning and memory between middle-aged female and male rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Estradiol and Estrogen-like Alternative Therapies in Use: The Importance of the Selective and Non-Classical Actions.Biomedicines · 2022Review
- Effects of Radix Polygalae on Cognitive Decline and Depression in Estradiol Depletion Mouse Model of Menopause.Current issues in molecular biology · 2021Article
- Development of a Chemical Reproductive Aging Model in Female Rats.Bio-protocol · 2021Article
- Article
- The endocrine-brain-aging triad where many paths meet: female reproductive hormone changes at midlife and their influence on circuits important for learning and memory.Experimental gerontology · 2017Article
- Regulation of Gonadotropin-Releasing Hormone-(1-5) Signaling Genes by Estradiol Is Age Dependent.Frontiers in endocrinology · 2017Article
- Modeling menopause: The utility of rodents in translational behavioral endocrinology research.Maturitas · 2016Review
- A Novel, Stable, Estradiol-Stimulating, Osteogenic Yam Protein with Potential for the Treatment of Menopausal Syndrome.Scientific reports · 2015Article
- The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity.Neurobiology of aging · 2015Article
- Hypothalamic molecular changes underlying natural reproductive senescence in the female rat.Endocrinology · 2014Article
- G-protein coupled estrogen receptor, estrogen receptor α, and progesterone receptor immunohistochemistry in the hypothalamus of aging female rhesus macaques given long-term estradiol treatment.Journal of experimental zoology. Part A, Ecological genetics and physiology · 2014Article
- Effects of chronic NMDA-NR2b inhibition in the median eminence of the reproductive senescent female rat.Journal of neuroendocrinology · 2013Article
- Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons.Molecular endocrinology (Baltimore, Md.) · 2013Article
- The role of cAMP response element-binding protein in estrogen negative feedback control of gonadotropin-releasing hormone neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neuroendocrine control of the transition to reproductive senescence: lessons learned from the female rodent model.Neuroendocrinology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Reproductive aging in female rats is characterized by profound alterations in the neuroendocrine axis. The preovulatory luteinizing hormone (LH) surge is attenuated, and preovulatory expression of the immediate early gene fos in gonadotropin-releasing hormone (GnRH) neurons is substantially reduced in middle-aged compared with young rats. We tested the hypothesis that alterations in GnRH gene expression may be correlated with the attenuation of the LH surge and may be a possible mechanism involved in neuroendocrine senescent changes. Sprague-Dawley rats ages 4 to 5 mo (young), 12-14 mo (middle-aged), or 25 to 26 mo (old) were killed at 10:00 AM or 3:00 PM on proestrus, the day of the LH surge, or diestrus I in cycling rats, and on persistent estrus or persistent diestrus in acyclic rats. RNase protection assays of GnRH mRNA and GnRH primary transcript were performed. GnRH mRNA levels increased significantly with age, whereas GnRH primary transcript levels, an index of GnRH gene transcription, decreased in old compared to young and middle-aged rats. This latter result suggests that an age-related change in GnRH mRNA levels occurs independently of a change in gene transcription, indicating a potential posttranscriptional mechanism. On proestrus, GnRH mRNA levels increased significantly from 10:00 AM to 3:00 PM in young rats. This was in contrast to proestrous middle-aged rats, in which this afternoon increase in GnRH mRNA levels was not observed. Thus, the normal afternoon increase in GnRH mRNA levels on proestrus is disrupted by middle age and may represent a substrate for the attenuation of the preovulatory GnRH/LH surge that occurs in rats of this age, prior to reproductive failure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.