ReviewCritical care (London, England)2000
Debate: Albumin administration should be avoided in the critically ill.
Review in Critical care (London, England), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Recommendations for the use of albumin and immunoglobulins.Blood transfusion = Trasfusione del sangue · 2009Guideline
- Plasma colloid osmotic pressure in healthy infants.Critical care (London, England) · 2001Trial
- Early albumin infusion and mortality in ICU patients with HFpEF: a target trial emulation study.European journal of clinical pharmacology · 2026Article
- Article
- Article
- Association Between 25% Albumin and Fluid Balance in Mechanically Ventilated Children.Respiratory care · 2025Article
- The Efficacy of Albumin Infusion in Septic Patients with Hypoalbuminemia: An International Retrospective Observational Study.Journal of clinical medicine · 2025Article
- Exploring treatment effects and fluid resuscitation strategies in septic shock: a deep learning-based causal inference approach.Scientific reports · 2025Article
- [Association between serum albumin levels after albumin infusion and 28-day mortality in critically ill patients with acute kidney injury].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Chronic Edema Management of the Lower Extremities.Cureus · 2024Review
- Role of albumin infusion in cirrhosis-associated complications.Clinical and experimental medicine · 2024Review
- Protein "purity," proteoforms, and the albuminome: critical observations on proteome and systems complexity.Frontiers in cell and developmental biology · 2024Article
- Peptide derivedHeliyon · 2023Article
- Biodegradable Biopolymeric Nanoparticles for Biomedical Applications-Challenges and Future Outlook.Materials (Basel, Switzerland) · 2023Review
- Association between 20% Albumin Use and Acute Kidney Injury in Major Abdominal Surgery with Transfusion.International journal of molecular sciences · 2023Article
- Comparison of Albumin and Fresh Frozen Plasma as Colloid Therapy in Patients With Major Burns.Cureus · 2023Article
- Heparin Resistance During Cardiopulmonary Bypass in Adult Cardiac Surgery.Journal of cardiothoracic and vascular anesthesia · 2022Review
- Albumin as a Biomaterial and Therapeutic Agent in Regenerative Medicine.International journal of molecular sciences · 2022Review
- Albumin Might Attenuate Bacteria-Induced Damage on Kupffer Cells for Patients with Chronic Liver Disease.Cells · 2021Article
- Noncalcific Mechanisms of Bioprosthetic Structural Valve Degeneration.Journal of the American Heart Association · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The benefit of albumin administration in the critically ill patient is unproven. Epidemiological evidence suggests that there is an increase in death among patients with burns, hypoalbuminaemia, and hypotension treated with human albumin solution (HAS). In critical illness, hypoalbuminaemia is a result of transcapillary leak, decreased synthesis, large volume body fluid losses, and dilution caused by fluid resuscitation. When treating patients with hypoalbuminaemia, efforts must be centred around correction of the underlying disorder rather than reversal of hypoalbuminaemia. Problems with using albumin arise because it is an expensive blood product, and can result in systemic changes that include cardiovascular, haematological, renal, pulmonary, and immunological effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.