ArticleJournal of molecular neuroscience : MN2000
Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities.
Article in Journal of molecular neuroscience : MN, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor.Aging cell · 2021Article
- p75NTR promotes survival of breast cancer resistant cells by regulating Bcl-2/Bax and MAPK pathway.International journal of clinical and experimental pathology · 2017Article
- Prediction of functional phosphorylation sites by incorporating evolutionary information.Protein & cell · 2012Article
- Neurotrophins in healthy and diseased skin.Dermato-endocrinology · 2011Article
- PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts.The EMBO journal · 2003Article
- Role of tyrosine phosphorylation in the antioxidant effects of the p75 neurotrophin receptor.Oxidative medicine and cellular longevityArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The signaling pathways invoked by ligand binding to the common neurotrophin receptor p75NTR are incompletely understood. Using the yeast two-hybrid system, we identified the mitogen-activated protein (MAP) kinase p38beta2 as a specific interactor with the 5th and 6th alpha helices of the p75NTR intracytoplasmic region. The consequences of this interaction were studied, using primary cultures of Schwann cells and the 293T cell line. Phosphorylation of p75NTR by p38beta2 was induced in vitro and in vivo by MAP kinase kinases (MKK) 6 activation. This pathway demonstrated feedback in that nerve growth factor (NGF) binding increased p38beta2 activity, causing an increase of nuclear factor-kappaB (NF-kappaB) activation and a decrease of AP-1 activation. The mechanisms described explain at least in part why NGF binding to p75NTR increases cell survival in certain circumstances.
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Registered trials
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