ArticleThe Journal of physiology2001
Role of muscle tone in peristalsis in guinea-pig small intestine.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Smooth Muscle Mechanosensitivity Generates and Maintains Pressure Gradients Across the Intestine.Neurogastroenterology and motility · 2026Article
- Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract.International journal of molecular sciences · 2022Review
- Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility.Nature reviews. Gastroenterology & hepatology · 2020Review
- Article
- Transforming growth factor-beta 3 alters intestinal smooth muscle function: implications for gastroschisis-related intestinal dysfunction.Digestive diseases and sciences · 2015Article
- Gastrointestinal motility and its enteric actors in mechanosensitivity: past and present.Pflugers Archiv : European journal of physiology · 2015Review
- Mechanosensitivity in the enteric nervous system.Frontiers in cellular neuroscience · 2015Review
- Assessment of the anti-diarrhea function of compound Chinese herbal medicine Cangpo Oral Liquid.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2014Article
- Article
- Effects of nonocclusive mesenteric hypertension on intestinal function: implications for gastroschisis-related intestinal dysfunction.Pediatric research · 2012Article
- Purinergic mechanisms in the control of gastrointestinal motility.Purinergic signalling · 2008Article
- High definition mapping of circular and longitudinal motility in the terminal ileum of the brushtail possum Trichosurus vulpecula with watery and viscous perfusates.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2007Article
- Synaptic transmission at functionally identified synapses in the enteric nervous system: roles for both ionotropic and metabotropic receptors.Current neuropharmacology · 2007Article
- Sensory elements within the circular muscle are essential for mechanotransduction of ongoing peristaltic reflex activity in guinea-pig distal colon.The Journal of physiology · 2006Article
- Viscoelastic behaviour aids extrusion from and reabsorption of the liquid phase into the digesta plug: creep rheometry of hindgut digesta in the common brushtail possum Trichosurus vulpecula.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2006Article
- Segmentation induced by intraluminal fatty acid in isolated guinea-pig duodenum and jejunum.The Journal of physiology · 2004Article
- Long vasodilator reflexes projecting through the myenteric plexus in guinea-pig ileum.The Journal of physiology · 2003Article
- A smooth muscle tone-dependent stretch-activated migrating motor pattern in isolated guinea-pig distal colon.The Journal of physiology · 2003Article
- A rhythmic motor pattern activated by circumferential stretch in guinea-pig distal colon.The Journal of physiology · 2002Article
- Slow excitatory synaptic potentials evoked by distension in myenteric descending interneurones of guinea-pig ileum.The Journal of physiology · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the involvement of muscle tone and circular muscle (CM) contraction in peristalsis in isolated guinea-pig small intestine. A segment of jejunum (approximately 13 cm) was mounted into a three chambered partitioned bath. Peristaltic waves were initiated in the oral chamber either by: (1) infusing fluid into the oral end of the jejunum; the ejected fluid was diverted via a cannula from reaching the intermediate and anal chambers, or by (2) intraluminal balloon distension of the empty oral segment. Tension of the circular muscle was measured in all three chambers. Peristaltic waves elicited by fluid infusion were evoked at an abrupt threshold. In contrast, peristaltic waves elicited by distension could be graded in amplitude according to stimulus intensity. Peristaltic waves evoked in an empty intestine exhibited similar propagation velocities to peristaltic waves associated with fluid propulsion. Nifedipine (200-400 nM) added to the intermediate chamber to block muscle contraction did not prevent peristaltic waves elicited by either stimulus from propagating into the anal chamber, although their amplitude was attenuated. Nifedipine to the site of stimulation (oral chamber) abolished peristaltic waves generated by either stimulus. Tetrodotoxin (1-2 microM), or a low Ca2+-high Mg2+ solution to the intermediate chamber abolished the propagation of peristalsis from the oral to anal chambers. In conclusion, graded peristaltic waves can occur in an empty intestine. Therefore peristalsis is not necessarily an "all-or-none" phenomenon. Peristalsis depends on the spread of nervous activity along the bowel, rather than the reactivation of neural circuits caused by displacement of fluid in the lumen. However, local muscle tone and contraction are important for the initiation and maintenance of peristaltic propagation.
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