ArticleThe Journal of physiology2001
Optical recordings of taste responses from fungiform papillae of mouse in situ.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Quantitative evaluation of sweet-responsive type II cells in mouse taste buds via biocytin uptake.Histochemistry and cell biology · 2025Article
- Characteristics of A-type voltage-gated KCell and tissue research · 2024Article
- Taste Receptor Cells Generate Oscillating Receptor Potentials by Activating G Protein-Coupled Taste Receptors.Frontiers in physiology · 2022Article
- Slow recovery from the inactivation of voltage-gated sodium channel Nav1.3 in mouse taste receptor cells.Pflugers Archiv : European journal of physiology · 2021Article
- Cell-type-independent expression of inwardly rectifying potassium currents in mouse fungiform taste bud cells.Physiological research · 2020Article
- Sensing Senses: Optical Biosensors to Study Gustation.Sensors (Basel, Switzerland) · 2020Review
- Coding in the mammalian gustatory system.Trends in neurosciences · 2010Review
- Functional expression of ionotropic purinergic receptors on mouse taste bud cells.The Journal of physiology · 2007Article
- Lucifer Yellow slows voltage-gated Na+ current inactivation in a light-dependent manner in mice.The Journal of physiology · 2003Article
- Electrophysiological characterization of voltage-gated currents in defined taste cell types of mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Individual mouse taste cells respond to multiple chemical stimuli.The Journal of physiology · 2002Article
- Postnatal development of membrane excitability in taste cells of the mouse vallate papilla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Distribution of gustatory sensitivities in rat taste cells: whole-cell responses to apical chemical stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single taste buds in mouse fungiform papillae consist of approximately 50 elongated cells (TBCs), where fewer than three TBCs have synaptic contacts with taste nerves. We investigated whether the non-innervated TBCs were chemosensitive using a voltage-sensitive dye, tetramethylrhodamine methyl ester (TMRM), under in situ optical recording conditions. Prior to the optical recordings, we investigated the magnitude and polarity of receptor potentials under in situ whole-cell clamp conditions. In response to 10 mM HCl, several TBCs were depolarized by approximately 25 mV and elicited action potentials, while other TBCs were hyperpolarized by approximately 12 mV. The TBCs eliciting hyperpolarizing receptor potentials also generated action potentials on electrical stimulation. A mixture of 100 mM NaCl, 10 mM HCl and 500 mM sucrose depolarized six TBCs and hyperpolarized another three TBCs out of 13 identified TBCs in a taste bud viewed by optical section. In an optical section of another taste bud, 1 M NaCl depolarized five TBCs and hyperpolarized another two TBCs out of 11 identified TBCs. The number of chemosensitive TBCs was much larger than the number of innervated TBCs in a taste bud, indicating the existence of chemosensitivity in non-innervated TBCs. There was a tendency for TBCs eliciting the same polarity of receptor potential to occur together in taste buds. We discuss the role of non-innervated TBCs in taste information processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.