ArticleJournal of bacteriology2001
Effects exerted by transcriptional regulator PcaU from Acinetobacter sp. strain ADP1.
Article in Journal of bacteriology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Mechanistic Modeling of Biochemical Systems without A Priori Parameter Values Using the Design Space Toolbox v.3.0.iScience · 2020Article
- Molecular control of gene expression byThe Journal of biological chemistry · 2018Article
- Towards the complete proteinaceous regulome ofMicrobial genomics · 2017Article
- A functional 4-hydroxybenzoate degradation pathway in the phytopathogen Xanthomonas campestris is required for full pathogenicity.Scientific reports · 2015Article
- GenR, an IclR-type regulator, activates and represses the transcription of gen genes involved in 3-hydroxybenzoate and gentisate catabolism in Corynebacterium glutamicum.Journal of bacteriology · 2013Article
- PcaO positively regulates pcaHG of the beta-ketoadipate pathway in Corynebacterium glutamicum.Journal of bacteriology · 2010Article
- The Acinetobacter baylyi Hfq gene encodes a large protein with an unusual C terminus.Journal of bacteriology · 2009Article
- Regulation of expression of genes involved in quinate and shikimate utilization in Corynebacterium glutamicum.Applied and environmental microbiology · 2009Article
- Role of Acinetobacter baylyi Crc in catabolite repression of enzymes for aromatic compound catabolism.Journal of bacteriology · 2009Article
- Multiple-level regulation of genes for protocatechuate degradation in Acinetobacter baylyi includes cross-regulation.Applied and environmental microbiology · 2007Article
- Characterization of the beta-ketoadipate pathway in Sinorhizobium meliloti.Applied and environmental microbiology · 2006Article
- Transcriptional organization of genes for protocatechuate and quinate degradation from Acinetobacter sp. strain ADP1.Applied and environmental microbiology · 2005Article
- Bacterial transcriptional regulators for degradation pathways of aromatic compounds.Microbiology and molecular biology reviews : MMBR · 2004Review
- NpdR, a repressor involved in 2,4,6-trinitrophenol degradation in Rhodococcus opacus HL PM-1.Journal of bacteriology · 2004Article
- Transcriptional cross-regulation of the catechol and protocatechuate branches of the beta-ketoadipate pathway contributes to carbon source-dependent expression of the Acinetobacter sp. strain ADP1 pobA gene.Applied and environmental microbiology · 2003Article
- Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.Journal of bacteriology · 2003Article
- Differential DNA binding of transcriptional regulator PcaU from Acinetobacter sp. strain ADP1.Journal of bacteriology · 2002Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protocatechuate degradation is accomplished in a multistep inducible catabolic pathway in Acinetobacter sp. strain ADP1. The induction is brought about by the transcriptional regulator PcaU in concert with the inducer protocatechuate. PcaU, a member of the new IclR family of transcriptional regulators, was shown to play a role in the activation of transcription at the promoter for the structural pca genes, leaving open the participation of additional activators. In this work we show that there is no PcaU-independent transcriptional activation at the pca gene promoter. The minimal inducer concentration leading to an induction response is 10(-5) M protocatechuate. The extent of expression of the pca genes was observed to depend on the nature of the inducing carbon source, and this is assumed to be caused by different internal levels of protocatechuate in the cells. The basal level of expression was shown to be comparatively high and to vary depending on the noninducing carbon source independent of PcaU. In addition to the activating function, in vivo results suggest a repressing function for PcaU at the pca gene promoter in the absence of an elevated inducer concentration. Expression at the pcaU gene promoter is independent of the growth condition but is subject to strong negative autoregulation. We propose a model in which PcaU exerts a repressor function both at its own promoter and at the structural gene promoter and in addition functions as an activator of transcription at the structural gene promoter at elevated inducer concentration.
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