ArticleHypertension (Dallas, Tex. : 1979)2001
Thyroid Hormone Stimulates Renin Gene Expression Through the Thyroid Hormone Response Element.
Article in Hypertension (Dallas, Tex. : 1979), 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
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- In silico development of RNA aptamer candidates against thyroid receptor.Journal of computer-aided molecular design · 2025Article
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- Assessment of the renal function of patients with anorexia nervosa.BioPsychoSocial medicine · 2024Article
- Treatment of hypothyroidism improves glomerular filtration rate (GFR) in geriatric patientsTurkish journal of medical sciences · 2021Article
- The effect of eplerenone on the renin-angiotensin-aldosterone system of rats with thyroid dysfunction.The Journal of pharmacy and pharmacology · 2019Article
- Evaluation of Daily Blood Pressure Alteration in Subclinical Hypothyroidism.Acta Cardiologica Sinica · 2017Article
- High glucose augments angiotensinogen in human renal proximal tubular cells through hepatocyte nuclear factor-5.PloS one · 2017Article
- Disturbed expression and distribution of myocardial connexin 43 in sudden death patients with hyperthyroid heart disease.International journal of clinical and experimental pathology · 2017Article
- Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Contribution of a nuclear factor-kappaB binding site to human angiotensinogen promoter activity in renal proximal tubular cells.Hypertension (Dallas, Tex. : 1979) · 2011Article
- Crucial role of Rho-nuclear factor-kappaB axis in angiotensin II-induced renal injury.American journal of physiology. Renal physiology · 2007Article
- Sustained renal interstitial macrophage infiltration following chronic angiotensin II infusions.American journal of physiology. Renal physiology · 2007Article
- Thyroid hormone and blood pressure regulation.Current hypertension reports · 2003Review
- The association between renin and thyroid-related biomarkers with clinical characteristics and outcomes in hyperthyroid patients.Science progressArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
-We previously reported that thyroid hormone stimulates renin synthesis in vivo and in vitro. Here, we analyzed the 5'-flanking sequence of the human renin gene for promoter activity responsive to thyroid hormone using Calu-6 cells, which secrete renin endogenously and express thyroid hormone receptor-ss. The luciferase reporter gene was cloned together with 5'-flanking portions of the human renin gene of various lengths into the pGL3-Basic vector. Luciferase activity assays were performed using the Dual Luciferase Reporter Assay System. 3,3',5-Triiodo-L-thyronine stimulated the promoter activity of pGL3-Basic-1111/+12 and pGL3-Basic-1298/+12 by 2.3+/-0.1- and 1.7+/-0.1-fold, respectively. Shorter constructs (pGL3-Basic-144/+12, pGL3-Basic-226/+12, pGL3-Basic-452/+12, and pGL3-Basic-953/+12) were not stimulated by thyroid hormone. These results suggest that there is a possible thyroid hormone response element (5'-AGG TCA GGT CAc aat GTT CCT-3') between nucleotides -1111 and -953. In 3 constructs with site-directed mutations in this sequence, basal promoter activities were significantly increased, whereas promoter activation by thyroid hormone was abolished. Electrophoretic mobility shift assays showed that the -1111/-953 DNA fragment of the intact human renin gene was bound to nuclear proteins of Calu-6 cells; however, none of the 3 mutant probes were bound to any nuclear proteins. These results suggest that thyroid hormone stimulates the promoter activity of the human renin gene through thyroid hormone response element-dependent mechanisms in Calu-6 cells.
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Registered trials
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