ArticleCell2001
RETRACTED: Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans.
Article in Cell, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 119 citations in OpenAlex.
- Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing.Nature communications · 2019Article
- Article
- Viral-derived complement inhibitors: current status and potential role in immunomodulation.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology.Scientific reports · 2016Article
- The agnoprotein of polyomavirus JC is released by infected cells: evidence for its cellular uptake by uninfected neighboring cells.Virology · 2014Article
- Demystifying heparan sulfate-protein interactions.Annual review of biochemistry · 2014Review
- Conformational states of a bacterial α2-macroglobulin resemble those of human complement C3.PloS one · 2012Article
- Disabling complement regulatory activities of vaccinia virus complement control protein reduces vaccinia virus pathogenicity.Vaccine · 2011Article
- Enhancing complement control on endothelial barrier reduces renal post-ischemia dysfunction.The Journal of surgical research · 2011Article
- Influence of glycosylation and oligomerization of vaccinia virus complement control protein on level and pattern of functional activity and immunogenicity.Protein & cell · 2010Article
- Ectromelia virus inhibitor of complement enzymes protects intracellular mature virus and infected cells from mouse complement.Journal of virology · 2010Article
- MHV68 complement regulatory protein facilitates MHV68 replication in primary macrophages in a complement independent manner.Virology · 2010Article
- Fraud rocks protein community.Nature · 2009Article
- Poxvirus proteomics and virus-host protein interactions.Microbiology and molecular biology reviews : MMBR · 2009Review
- Smallpox inhibitor of complement enzymes (SPICE): dissecting functional sites and abrogating activity.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation.Acta crystallographica. Section D, Biological crystallography · 2009Article
- Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood.Infection and immunity · 2009Article
- Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations.The Journal of biological chemistry · 2008Article
- Identification of hot spots in the variola virus complement inhibitor (SPICE) for human complement regulation.Journal of virology · 2008Article
Corrections and comments
- Retraction · 2018-12-13Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Krishna H M Murthy aka H M Krishna Murthy; H M Krishna Murthy has NIH finding of misconduct: https://www.federalregister.gov/documents/2018/04/16/2018-07782/findings-of-research-misconduct
- Commented on by
- Retracted
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of request of the editors. Cell is retracting this paper reporting structures of a poxvirus protein, VCP, that inhibits the complement system. The paper presents a structural model derived from two crystal forms of the protein (PDB: 1G40 and 1G44) that defines an interaction surface implicated in inhibition of complement C3 proteins and visualizes heparin binding sites. We were contacted by the University of Alabama, Birmingham (UAB), the corresponding author's institution, with a report detailing concerns about the veracity of the structures and recommending that the structures be retracted from the Protein Data Bank. We then conducted an assessment with input from experts in the field who found that the structures as presented in the paper were not consistent with available data, including spatial packing and structure (B) factors. These findings were consistent with issues contained in the UAB report. A subsequent investigation by the Department of Health and Human Services Office of Research Integrity (https://www.federalregister.gov/documents/2018/04/16/2018-07782/findings-of-research-misconduct) has concluded that the corresponding author, Krishna H.M. Murthy, engaged in research misconduct and that the structures were falsified and/or fabricated. Given the results of our own assessment and the institutional investigations, the most appropriate course of action is to retract the paper. Co-authors Nick Mullin, Paul N. Barlow, and Craig M. Ogata support this retraction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.