ArticleJournal of muscle research and cell motility2000
Myostatin levels in regenerating rat muscles and in myogenic cell cultures.
Article in Journal of muscle research and cell motility, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- The effects of resistance training on myostatin in older adults with frailty and/or sarcopenia: a systematic review and meta analysis.BMC sports science, medicine & rehabilitation · 2026Article
- Chestnut (Nutrients · 2025Article
- Characterization of Skeletal Muscle Regeneration Revealed a Novel Growth Network Induced by Molecular Acupuncture-like Transfection.Biomolecules · 2024Review
- Effects of Two Fractions of Swietenia macrophylla and Catechin on Muscle Damage Induced by BothropsVenom and PLA₂.Toxins · 2019Article
- A non-human primate model of radiation-induced cachexia.Scientific reports · 2016Article
- Myostatin and IGF-I signaling in end-stage human heart failure: a qRT-PCR study.Journal of translational medicine · 2015Article
- The compact mutation of myostatin causes a glycolytic shift in the phenotype of fast skeletal muscles.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Blocking the myostatin signal with a dominant negative receptor improves the success of human myoblast transplantation in dystrophic mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.The journal of physiological sciences : JPS · 2010Article
- A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization.Human reproduction (Oxford, England) · 2008Article
- Regeneration of reinnervated rat soleus muscle is accompanied by fiber transition toward a faster phenotype.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Article
- Contractile properties of EDL and soleus muscles of myostatin-deficient mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2006Article
- Exercise-induced signal transduction and gene regulation in skeletal muscle.Journal of sports science & medicine · 2002Review
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myostatin is a newly described member of the TGF-beta superfamily acting as a secreted negative regulator of skeletal muscle mass in several species, but whose mode of action remains largely unknown. In the present work, we followed the myostatin mRNA and protein levels in rat soleus and extensor digitorum longus (EDL) muscles regenerating in vivo from notexin-induced necrosis, and the myostatin transcript levels in two different in vitro myogenic differentiation models: i.e. in mouse BC3H1 and C2Cl2 cultured cells. The in vivo regenerating rat skeletal muscles showed a characteristic time-dependent expression of myostatin mRNA. After notexin injection, the transcript levels dropped below the detection limit on day 1 in soleus and close to the detection limit on day 3 in EDL, then increased to a maximum on day 7 in soleus and after 28 days finally reached the control values in both types of muscles. In contrast, the myostatin protein levels increased dramatically on the first days of regeneration in both muscles, i.e. at the time when its transcript level was low. Later on the myostatin protein level gradually declined to normal in soleus while in EDL it stayed high some days longer and decreased to normal on days 21-28. In vitro proliferating myoblasts produced low level of myostatin mRNA, which increased upon induction of differentiation suggesting that functional innervation is no prerequisite for myostatin expression. Myostatin production in vitro seems not to be dependent on myocyte fusion either, since it is observed in differentiated BC3H1 cells, which are defective in myofiber formation.
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