ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2001
DNA polymerase mu, a candidate hypermutase?
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- The mechanisms of human lymphoid chromosomal translocations and their medical relevance.Critical reviews in biochemistry and molecular biology · 2022Article
- PrimPol: A Breakthrough among DNA Replication Enzymes and a Potential New Target for Cancer Therapy.Biomolecules · 2022Review
- Pol μ ribonucleotide insertion opposite 8-oxodG facilitates the ligation of premutagenic DNA repair intermediate.Scientific reports · 2020Article
- Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism.Annual review of biochemistry · 2018Review
- Decision-making during NHEJ: a network of interactions in human Polμ implicated in substrate recognition and end-bridging.Nucleic acids research · 2014Article
- A specific N-terminal extension of the 8 kDa domain is required for DNA end-bridging by human Polμ and Polλ.Nucleic acids research · 2013Article
- DNA expansions generated by human Polμ on iterative sequences.Nucleic acids research · 2013Article
- Modulation of Pleurodeles waltl DNA polymerase mu expression by extreme conditions encountered during spaceflight.PloS one · 2013Article
- DNA-binding determinants promoting NHEJ by human Polμ.Nucleic acids research · 2012Article
- Patching and single-strand ligation in nonhomologous DNA end joining despite persistence of a closely opposed 3'-phosphoglycolate-terminated strand break.Radiation research · 2010Article
- Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase.Biochimica et biophysica acta · 2010Review
- Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair.PLoS genetics · 2009Article
- ASFV DNA polymerse X is extremely error-prone under diverse assay conditions and within multiple DNA sequence contexts.Biochemistry · 2006Article
- A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis.Nucleic acids research · 2006Article
- Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe.Nucleic acids research · 2005Article
- Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate.Nucleic acids research · 2004Article
- Terminal deoxynucleotidyl transferases from elasmobranchs reveal structural conservation within vertebrates.Immunogenetics · 2003Article
- Mutagenesis of human DNA polymerase lambda: essential roles of Tyr505 and Phe506 for both DNA polymerase and terminal transferase activities.Nucleic acids research · 2003Article
- Lack of sugar discrimination by human Pol mu requires a single glycine residue.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel DNA polymerase (Pol mu) has been recently identified in human cells. The amino-acid sequence of Pol mu is 42% identical to that of terminal deoxynucleotidyl transferase (TdT), a DNA-independent DNA polymerase that contributes to antigen-receptor diversity. In this paper we review the evidence supporting the role of Pol mu in somatic hypermutation of immunoglobulin genes, a T-dependent process that selectively occurs at germinal centres: (i) preferential expression in secondary lymphoid organs; (ii) expression associated to developing germinal centres; and (iii) very low base discrimination during DNA-dependent DNA polymerization by Pol mu, a mutator phenotype enormously accentuated by the presence of activating Mn2+ ions. Moreover, its similarity to TdT, together with extrapolation to the crystal structure of DNA polymerase beta complexed (Pol beta) with DNA, allows us to discuss the structural basis for the unprecedented error proneness of Pol mu, and to predict that Pol mu is structurally well suited to participate also in DNA end-filling steps occurring both during V(D)J recombination and repair of DNA double-strand breaks that are processed by non-homologous end-joining.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.