ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2001
In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination.Microbiology spectrum · 2015Review
- Article
- DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.PLoS biology · 2007Article
- H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation.The Journal of experimental medicine · 2003Article
- DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.The Journal of experimental medicine · 2002Article
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Authors and funding
8 authors.
Funding
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Abstract
Following antigen encounter, two distinct processes modify immunoglobulin genes. The variable region is diversified by somatic hypermutation while the constant region may be changed by class-switch recombination. Although both genetic events can occur concurrently within germinal centre B cells, there are examples of each occurring independently of the other. Here we compare the contributions of class-switch recombination and somatic hypermutation to the diversification of the serum immunoglobulin repertoire and review evidence that suggests that, despite clear differences, the two processes may share some aspects of their mechanism in common.
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