ReviewMolecular and cellular biochemistry2000
Free radicals, cytokines and nitric oxide in cardiac failure and myocardial infarction.
Review in Molecular and cellular biochemistry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Association of admission hyperglycemia and all-cause mortality in acute myocardial infarction with percutaneous coronary intervention: A dose-response meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Positive association between stress hyperglycemia ratio and ICU mortality in patients with pulmonary embolism: A retrospective study.PloS one · 2025Article
- Relationship between stress hyperglycaemic ratio and incidence of in-hospital cardiac arrest in patients with acute coronary syndrome: a retrospective cohort study.Cardiovascular diabetology · 2024Article
- Sarcopenia and Frailty in Heart Failure: Is There a Biomarker Signature?Current heart failure reports · 2022Review
- The Role of Sarcopenia in Heart Failure with Depression.Reviews in cardiovascular medicine · 2022Review
- Stress-Induced Hyperglycaemia in Non-Diabetic Patients with Acute Coronary Syndrome: From Molecular Mechanisms to New Therapeutic Perspectives.International journal of molecular sciences · 2021Review
- Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation.European heart journal · 2020Article
- Estrogen and Bisphenol A in Hypertension.Current hypertension reports · 2020Review
- Sarcopenia and Heart Failure.Nutrients · 2020Review
- Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Sarcopenia in heart failure: mechanisms and therapeutic strategies.Journal of geriatric cardiology : JGC · 2016Review
- The effect of bisphenol A on some oxidative stress parameters and acetylcholinesterase activity in the heart of male albino rats.Cytotechnology · 2015Article
- Evaluation of oxidative stress and antioxidant status in patients with cardiovascular disease in rural populations of the nilgiris, South India.ISRN pharmacology · 2012Article
- The Utility of Animal Models in Understanding Links between Psychosocial Processes and Cardiovascular Health.Social and personality psychology compass · 2011Article
- Mechanisms underlying altered mood and cardiovascular dysfunction: the value of neurobiological and behavioral research with animal models.Neuroscience and biobehavioral reviews · 2009Review
- Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models.Stress (Amsterdam, Netherlands) · 2009Review
- Can endogenous lipid molecules serve as predictors and prognostic markers of coronary heart disease?Lipids in health and disease · 2008Article
- Free radical-induced protein modification and inhibition of Ca2+-ATPase of cardiac sarcoplasmic reticulum.Molecular and cellular biochemistry · 2003Article
- Interaction of physical training and chronic nitroglycerin treatment on blood pressure and plasma oxidant/antioxidant systems in rats.Molecular and cellular biochemistry · 2003Article
- The therapeutic effect of natriuretic peptides in heart failure; differential regulation of endothelial and inducible nitric oxide synthases.Heart failure reviews · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardial infarction is the most common cause of congestive cardiac failure. Free radicals, cytokines, nitric oxide (NO) and antioxidants play a major role both in atherosclerosis and myocardial damage and preservation. In the early stages of atherosclerosis, neutrophils and monocytes infiltrate the intima and generate free radicals which damage the endothelial cells. As a result, production of NO and prostacyclin by the endothelial cells declines, which have cardioprotective actions. This also has relevance to the beneficial action of aspirin since, it can modulate both prostanoid and L-arginine-NO systems and NF-kB translocation. In both acute myocardial infarction and chronic congestive cardiac failure, the plasma levels of various inflammatory mediators such as interleukins and tumour necrosis factor-alpha (TNFalpha) are elevated. TNFalpha, produced by the inflammatory cells and the myocardium, can suppress myocardial contractility and induce the production of free radicals, which in turn can further damage the myocardium. Transforming growth factor beta (TGFbeta), polyunsaturated fatty acids and the glucose-insulin-potassium regimen can antagonize the harmful actions of TNFalpha and protect the myocardium. This explains why efforts made to reduce the levels of pro-inflammatory cytokines have beneficial action and preserve the myocardium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.