Trial reportCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2001
Effect of domperidone on milk production in mothers of premature newborns: a randomized, double-blind, placebo-controlled trial.
Trial report in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03221855 (Randomized Clinical Trial), which is not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Clinical Trial: Use of Domperidone to Increase Milk Production in Mothers With Newborns Hospitalized in Neonatology
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis.Clinical drug investigation · 2016Pooled it
- Prevalence and outcomes of breast milk expressing in women with healthy term infants: a systematic review.BMC pregnancy and childbirth · 2013Pooled it
- Medications for increasing milk supply in mothers expressing breastmilk for their preterm hospitalised infants.The Cochrane database of systematic reviews · 2012Pooled it
- Infants admitted to neonatal units--interventions to improve breastfeeding outcomes: a systematic review 1990-2007.Maternal & child nutrition · 2008Pooled it
- Efficacy of Wang Nam Yen herbal tea on human milk production: A randomized controlled trial.PloS one · 2022Trial
- Role of days postdelivery on breast milk production: a secondary analysis from theInternational breastfeeding journal · 2019Trial
- Enhancing breast milk production with Domperidone in mothers of preterm neonates (EMPOWER trial).BMC pregnancy and childbirth · 2012Trial
- Recombinant human prolactin for the treatment of lactation insufficiency.Clinical endocrinology · 2010Trial
- Dose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk.British journal of clinical pharmacology · 2008Trial
- Randomised, double blind trial of oxytocin nasal spray in mothers expressing breast milk for preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2006Trial
- SUpporting Mothers Milk Intervention Trial (SUMMIT) - a randomised controlled trial comparing different doses of domperidone for treating lactation insufficiency in mothers of preterm infants - study protocol.International breastfeeding journal · 2026Article
- Efficacy and safety of domperidone and metoclopramide on human milk production in postpartum mothers: a bayesian network meta-analysis of randomized controlled trials.BMC pregnancy and childbirth · 2024Article
- Longitudinal trends in domperidone dispensing to mothers of very preterm infants and its association with breast milk feeding at infant discharge: a retrospective study.BMJ paediatrics open · 2023Article
- What Evidence Do We Have for Pharmaceutical Galactagogues in the Treatment of Lactation Insufficiency?-A Narrative Review.Nutrients · 2019Review
- Effect of methanolic crude extract of Aframomum melegueta (A.m) seeds on selected lactogenic hormones of Albino rats.International journal of biochemistry and molecular biology · 2019Article
- Supporting Mothers of Very Preterm Infants and Breast Milk Production: A Review of the Role of Galactogogues.Nutrients · 2018Review
- Pregnancy gestation at delivery and breast milk production: a secondary analysis from theMaternal health, neonatology and perinatology · 2018Article
- Should Domperidone be Used as a Galactagogue? Possible Safety Implications for Mother and Child.Drug safety · 2017Article
- Maternal experiences with and sources of information on galactagogues to support lactation: a cross-sectional study.International journal of women's health · 2017Article
- Effect of Domperidone in 2nd week Postpartum on Milk Output in Mothers of Preterm Infants.Indian journal of pediatrics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarying degrees of success have been reported with strategies to increase milk production when lactation is failing. The objective of this study was to investigate the efficacy of domperidone in augmenting milk production in mothers of premature newborns.
methodsTwenty patients were randomly assigned to receive either domperidone or placebo for 7 days. Milk volume was measured daily. Domperidone levels were measured in randomly selected milk and serum samples on day 5 of the study. Serum prolactin levels were measured before the start of the study, on day 5 and on day 10 (3 days after the last dose of the study medication).
resultsData from 16 patients were available for analysis (7 in the domperidone group and 9 in the placebo group). When compared with baseline values, the mean increase in the volume of milk production from day 2 to 7 was 49.5 (standard deviation [SD] 29.4) mL in the domperidone group and 8.0 (SD 39.5) mL in the placebo group (p < 0.05); proportionally this represented an increase of 44.5% and 16.6% respectively. The serum prolactin levels were similar in the 2 groups at baseline; by day 5 they were significantly higher in the domperidone group than in the placebo group, returning to baseline levels in both groups 3 days after the last dose of the study medication. Very small amounts of domperidone were detected in the breast milk samples.
interpretationIn the short term domperidone increases milk production in women with low milk supply and is detected at low levels in breast milk.
Indexed as
Identifiers
11202662PMC80627W2169086846What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.