ArticleJournal of anatomy2000
Immunohistochemical analysis of development of desmin-positive hepatic stellate cells in mouse liver.
Article in Journal of anatomy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Size-Modulated Mesoderm-Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Immunoreactivity for CD34, Desmin, Keratins, KIT, Alpha-Smooth Muscle Actin, S100, and Vimentin in Malignant Mesenchymal Neoplasms in Guinea Pigs: A Series of 62 Cases From a Single Institution.Veterinary medicine and science · 2026Article
- Size-Modulated Mesoderm-Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids.bioRxiv : the preprint server for biology · 2025Article
- Article
- Fetal liver development and implications for liver disease pathogenesis.Nature reviews. Gastroenterology & hepatology · 2023Review
- Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2.JCI insight · 2022Article
- Optimization of the isolation procedure and culturing conditions for hepatic stellate cells obtained from mouse.Bioscience reports · 2021Article
- Article
- Bayesian correlation is a robust gene similarity measure for single-cell RNA-seq data.NAR genomics and bioinformatics · 2020Article
- Crosstalk Between the Hepatic and Hematopoietic Systems During Embryonic Development.Frontiers in cell and developmental biology · 2020Review
- Angiotensin II subtype 1a receptor signaling in resident hepatic macrophages induces liver metastasis formation.Cancer science · 2017Article
- A New Oleanolic Acid Derivative against CCl₄-Induced Hepatic Fibrosis in Rats.International journal of molecular sciences · 2017Article
- Expression profiling of adhesion proteins during prenatal and postnatal liver development in rats.Stem cells and cloning : advances and applications · 2017Article
- Desminopathies: pathology and mechanisms.Acta neuropathologica · 2013Review
- Hepatocyte polarity.Comprehensive Physiology · 2013Review
- Hepatic stellate cell progenitor cells.Journal of gastroenterology and hepatology · 2012Review
- Peroxisome proliferator-activated receptor agonist treatment of alcohol-induced hepatic insulin resistance.Hepatology research : the official journal of the Japan Society of Hepatology · 2011Article
- Hepatoblast and mesenchymal cell-specific gene-expression in fetal rat liver and in cultured fetal rat liver cells.Histochemistry and cell biology · 2009Article
- Promoter-defined isolation and identification of hepatic progenitor cells from the human fetal liver.Histochemistry and cell biology · 2008Article
- Immunohistochemical analyses of cell-cell interactions during hepatic organoid formation from fetal mouse liver cells cultured in vitro.Histochemistry and cell biology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of desmin-positive hepatic stellate cells was studied in mice using double immunofluorescent techniques and in vitro cultures with special attention given to their cell lineages. Several studies recently reported on the presence of cells that are immunologically reactive with both antidesmin and anticytokeratin antibodies in young fetal rat livers, and suggested the possibility that these cells give rise to hepatocytes and hepatic stellate cells. At early stages of mouse liver development, stellate cells with desmin-positive filaments were scattered in the liver parenchyma. However, the stellate cells definitely differed from hepatoblasts and hepatocytes in terms of their morphology and expression of desmin and hepatoblast and hepatocyte-specific E-cadherin in the liver. Fetal hepatoblasts and hepatocytes did not react with antidesmin antibodies, nor did desmin-positive stellate cells express E-cadherin in vivo and in vitro. Thus it is likely that desmin-positive stellate cells and hepatoblasts belong to different cell lineages. In the fetal liver, the desmin-positive stellate cells surrounded blood vessels, and extended their processes to haematopoietic cells and megakaryocytes. Many, but not all, hepatoblasts and hepatocytes were observed to be associated with the stellate cells. At fetal stages, cellular processes positive for desmin in the stellate cells were also thick compared with those in the adult liver, in which desmin-positive stellate cells lay in Disse's space and were closely associated with all hepatocytes. These developmental changes in the geography of desmin-positive cells in the liver parenchyma and their morphology may be associated with their maturation and interactions with other cell types.
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