ReviewJournal of anatomy2000
Glucocorticoids and the ageing hippocampus.
Review in Journal of anatomy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 101 citations in OpenAlex.
- Can Adults with Mild Cognitive Impairment Build Cognitive Reserve and Learn Mindfulness Meditation? Qualitative Theme Analyses from a Small Pilot Study.Journal of Alzheimer's disease : JAD · 2019Trial
- A pilot placebo-controlled, double-blind, and randomized study on the cognition-enhancing benefits of a proprietary chicken meat ingredient in healthy subjects.Nutrition journal · 2013Trial
- Age-related increase in the expression of 11β-hydroxysteroid dehydrogenase type 1 in the hippocampus of male rhesus macaques.Frontiers in aging neuroscience · 2024Article
- Functional Neurochemistry of the Ventral and Dorsal Hippocampus: Stress, Depression, Dementia and Remote Hippocampal Damage.Neurochemical research · 2019Article
- Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression.Journal of neuroinflammation · 2018Article
- Behavioral, Psychiatric, and Cognitive Adverse Events in Older Persons Treated with Glucocorticoids.Medicines (Basel, Switzerland) · 2018Review
- Coping with Stress During Aging: The Importance of a Resilient Brain.Current neuropharmacology · 2018Review
- Puerarin and Amlodipine Improvement of D-Galactose-Induced Impairments of Behaviour and Neurogenesis in Mouse Dentate Gyrus: Correlation with Glucocorticoid Receptor Expression.Neurochemical research · 2017Article
- Late-Onset Cognitive Impairments after Early-Life Stress Are Shaped by Inherited Differences in Stress Reactivity.Frontiers in cellular neuroscience · 2017Article
- Effects of neonatal stress on gamma oscillations in hippocampus.Scientific reports · 2016Article
- Interaction of basal forebrain cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment.Frontiers in aging neuroscience · 2015Review
- The impact of stress and glucocorticoids on memory.Clujul medical (1957) · 2014Review
- Elderly-onset sarcoidosis: prevalence, clinical course, and treatment.Drugs & aging · 2013Review
- MicroRNAs in the aging female brain: a putative mechanism for age-specific estrogen effects.Endocrinology · 2013Article
- Successful brain aging: plasticity, environmental enrichment, and lifestyle.Dialogues in clinical neuroscience · 2013Review
- Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids.Neurobiology of aging · 2012Article
- Progress in the development of new drugs in Alzheimer's disease.The journal of nutrition, health & aging · 2011Article
- Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus.Yonsei medical journal · 2010Article
- Neural circuitry associated with risk for alcohol use disorders.Neuropsychology review · 2010Review
- Glial glucocorticoid receptors in aged Fisher 344 (F344) and F344/Brown Norway rats.Experimental gerontology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately 30 % of human and mammalian populations develop cognitive impairments with ageing. Many of these impairments have been linked to dysfunction of the hippocampus, a well studied area of the medial-temporal lobe, which is involved in episodic memory and control of the hypothalamo-pituitary-adrenal stress axis and, thus, of glucocorticoid secretion. This paper reviews the growing body of studies which explore a possible relationship between lifetime exposure to glucocorticoids and hippocampal impairment. There is now strong evidence which associates hypercortisolemia in aged men with later cognitive dysfunction and this complements a wealth of rodent and other human data. We conclude with a discussion of possible pharmacological and behavioural interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.