ArticlePlant molecular biology2000
The role of hexokinase in plant sugar signal transduction and growth and development.
Article in Plant molecular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.
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Who cites it
145 citing papers in PubMed, 397 citations in OpenAlex.
- Altered Environmental Conditions Affect Responses to the Green Leaf VolatilePlants (Basel, Switzerland) · 2026Article
- Advances in the Regulatory Mechanism of Enzymes Involved in Soluble Sugar Metabolism in Fruits.Plants (Basel, Switzerland) · 2026Review
- Genome-wide identification of HXK gene families in cucumber and watermelon: CsHXK1 and ClHXK6 play key roles in responding to multiple stresses.BMC plant biology · 2026Article
- Decoding the sugar-strigolactone crosstalk: new frontier in plant growth and stress resilience.Horticulture research · 2026Article
- Integrative transcriptomic and proteomic analysis reveals the regulatory mechanisms underlying oilseed rape resistance to Leptosphaeria biglobosa.Frontiers in plant science · 2026Article
- Arabidopsis Ubiquitin E3 Ligase AtCHYR1 Promotes ROS Production in Plant Responses to Sugar Availability.Plants (Basel, Switzerland) · 2025Article
- Regulation of plant glycolysis and the tricarboxylic acid cycle by posttranslational modifications.The Plant journal : for cell and molecular biology · 2025Review
- The host and pathogen myo-inositol-1-phosphate synthases are required for Rhizoctonia solani AG1-IA infection in tomato.Molecular plant pathology · 2024Article
- A neutral invertase controls cell division besides hydrolysis of sucrose for nutrition during germination and seed setting in rice.iScience · 2024Article
- Iron rescues glucose-mediated photosynthesis repression during lipid accumulation in the green alga Chromochloris zofingiensis.Nature communications · 2024Article
- GmHXK2 promotes the salt tolerance of soybean seedlings by mediating AsA synthesis, and auxin synthesis and distribution.BMC plant biology · 2024Article
- Transcriptomics and metabolomics reveal the underlying mechanism of drought treatment on anthocyanin accumulation in postharvest blood orange fruit.BMC plant biology · 2024Article
- Sugar coordinates plant defense signaling.Science advances · 2024Article
- Article
- Diversification of plant SUPPRESSOR OF MAX2 1 (SMAX1)-like genes and genome-wide identification and characterization of cotton SMXL gene family.BMC plant biology · 2023Article
- Genome-Wide Characterization of Soybean Hexokinase Genes Reveals a Positive Role ofPlants (Basel, Switzerland) · 2023Article
- Transcriptomics and Metabolomics Analysis Provides Insight into Leaf Color and Photosynthesis Variation of the Yellow-Green Leaf Mutant of Hami Melon (Plants (Basel, Switzerland) · 2023Article
- Kinase CIPK9 integrates glucose and abscisic acid signaling to regulate seed oil metabolism in rapeseed.Plant physiology · 2023Article
- Characterization of hexokinase gene family members inFrontiers in genetics · 2023Article
- Hexokinase1: A glucose sensor involved in drought stress response and sugar metabolism depending on its kinase activity in strawberry.Frontiers in plant science · 2023Article
85 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have revealed a central role of Arabidopsis thaliana hexokinases (AtHXK1 and AtHXK2) in the glucose repression of photosynthetic genes and early seedling development. However, it remains unclear whether HXK can modulate the expression of diverse sugar-regulated genes. On the basis of the results of analyses of gene expression in HXK transgenic plants, we suggest that three distinct glucose signal transduction pathways exist in plants. The first is an AtHXK1-dependent pathway in which gene expression is correlated with the AtHXK1-mediated signaling function. The second is a glycolysis-dependent pathway that is influenced by the catalytic activity of both AtHXK1 and the heterologous yeast Hxk2. The last is an AtHXK1-independent pathway in which gene expression is independent of AtHXK1. Further investigation of HXK transgenic Arabidopsis discloses a role of HXK in glucose-dependent growth and senescence. In the absence of exogenous glucose, plant growth is limited to the seedling stage with restricted true leaf development even after a 3-week culture on MS medium. In the presence of glucose, however, over-expressing Arabidopsis or yeast HXK in plants results in the repression of growth and true leaf development, and early senescence, while under-expressing AtHXK1 delays the senescence process. These studies reveal multiple glucose signal transduction pathways that control diverse genes and processes that are intimately linked to developmental stages and environmental conditions.
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