ReviewGenes and immunity1999
Cytokine gene polymorphism in human disease: on-line databases.
Review in Genes and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
153 citing papers in PubMed, 7 syntheses or guidelines pooled it, 812 citations in OpenAlex.
- Interleukin 10 Polymorphisms as Risk Factors for Progression to Chagas Disease Cardiomyopathy: A Case-Control Study and Meta-Analysis.Frontiers in immunology · 2022Pooled it
- Pooled it
- The tumor necrosis factor-α-238 polymorphism and digestive system cancer risk: a meta-analysis.Clinical and experimental medicine · 2016Pooled it
- Evaluation of association of maternal IL-10 polymorphisms with risk of preeclampsia by A meta-analysis.Journal of cellular and molecular medicine · 2014Pooled it
- Association between tumor necrosis factor-alpha gene polymorphisms and prostate cancer risk: a meta-analysis.Diagnostic pathology · 2014Pooled it
- IL-10 promoter polymorphism associated with decreased risk of aGvHD after stem cell transplantation: a meta-analysis.International journal of hematology · 2013Pooled it
- Three polymorphisms in the IL-10 gene and the risk of HCV infection: a meta-analysis plus a Chinese Association Study involving 1140 subjects.Epidemiology and infection · 2013Pooled it
- TNF-α, IL6, and IL10 polymorphisms and the effect of physical exercise on inflammatory parameters and physical performance in elderly women.Age (Dordrecht, Netherlands) · 2013Trial
- The Role of Cytokine Gene Polymorphisms in Rehabilitation Outcome After Traumatic Brain Injury.Cells · 2025Article
- Cytokine gene polymorphisms and suicide risk in an Indian ancestral population: A case-control study.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2024Article
- Selected serum cytokines and vitamin D levels as potential prognostic markers of acute ischemic stroke.PloS one · 2024Article
- Genetic Predisposition to SARS-CoV-2 Infection: Cytokine Polymorphism and Disease Transmission within Households.Biology · 2023Article
- Genotoxicity of cytokines at chemotherapy-induced 'storm' concentrations in a model of the human bone marrow.Mutagenesis · 2023Article
- The etiological effect and genetic risk of +252 A/G variant of TNF-β gene related to the susceptibility of urinary tract infection in a sample of Iraqi patients with type 2 diabetes: A case control study.Health science reports · 2023Article
- Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics?World journal of gastroenterology · 2022Review
- TNFα rs1799964 TT genotype may be a susceptibility factor for vertical transmission of Toxoplasma gondii and clinical signs in newborns from pregnant women with acute toxoplasmosis.Molecular biology reports · 2022Article
- Single-Nucleotide Polymorphisms Within Non-HLA Regions Are Associated With Engraftment Effectiveness for Patients With Unrelated Cord Blood Transplantation.Frontiers in immunology · 2022Article
- Association of interleukin-18 genotypes (-607C > A) and (-137 G > C) with the hepatitis B virus disease progression to hepatocellular carcinoma.Molecular and cellular biochemistry · 2021Article
- Article
- Cytokine (IL-10, IL-6, TNF-α and TGF-β1) Gene Polymorphisms in Chronic Hepatitis C Virus Infection among Malay Male Drug Abusers.Biomedicines · 2021Article
93 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
11 authors at 10 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathologies of many infectious, autoimmune and malignant diseases are influenced by the profiles of cytokine production in pro-inflammatory (TH1) and anti-inflammatory (TH2) T cells. Interindividual differences in cytokine profiles appear to be due, at least in part, to allelic polymorphism within regulatory regions of cytokine gene. Many studies have examined the relationship between cytokine gene polymorphism, cytokine gene expression in vitro, and the susceptibility to and clinical severity of diseases. A review of the findings of these studies is presented. An on-line version featuring appropriate updates is accessible from the World Wide Web site, http://www.pam.bris.ac.uk/services/GAI/cytokine4.htm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.