ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2000
Gene density in the Giemsa bands of human chromosomes.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- QTL global meta-analysis: are trait determining genes clustered?BMC genomics · 2009Pooled it
- Plant Tolerance to Drought Stress with Emphasis on Wheat.Plants (Basel, Switzerland) · 2023Review
- Giemsa-negative chromosome bands preferentially recombine in cancer-associated translocations and gene fusions.Genes, chromosomes & cancer · 2023Article
- Article
- Chromosomal Rearrangements and Altered Nuclear Organization: Recent Mechanistic Models in Cancer.Cancers · 2021Review
- Long-range interactions between topologically associating domains shape the four-dimensional genome during differentiation.Nature genetics · 2019Article
- Article
- Disagreement between two common biomarkers of global DNA methylation.Clinical epigenetics · 2016Article
- The footprint of metabolism in the organization of mammalian genomes.BMC genomics · 2012Article
- Ab initio identification of functionally interacting pairs of cis-regulatory elements.Genome research · 2008Article
- The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density.Chromosoma · 2008Article
- Replication timing, chromosomal bands, and isochores.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Human chromosomal bands: nested structure, high-definition map and molecular basis.Chromosoma · 2007Article
- Gene-rich and gene-poor chromosomal regions have different locations in the interphase nuclei of cold-blooded vertebrates.Chromosoma · 2006Article
- Avian genomes: different karyotypes but a similar distribution of the GC-richest chromosome regions at interphase.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2005Article
- In silico chromosome staining: reconstruction of Giemsa bands from the whole human genome sequence.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Short interspersed transposable elements (SINEs) are excluded from imprinted regions in the human genome.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Genes, isochores and bands in human chromosomes 21 and 22.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2001Article
- Compositional mapping of chicken chromosomes and identification of the gene-richest regions.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human genome is formed by isochores belonging to five families, L1, L2, H1, H2 and H3, that are characterized by increasing GC levels and gene concentrations. In-situ hybridization of DNA from different isochore families provides, therefore, information not only on the correlation between isochores and chromosomal bands, but also on the distribution of genes in chromosomes. Three subsets of R(everse) bands were identified: H3+, H3* and H3-, that contain large, moderate, and no detectable amounts, respectively, of the gene-richest H2 and H3 isochores, and replicate very early and early, respectively, in S phase of the cell cycle. Here, we investigated the GC levels, replication timings and DNA compaction of G(iemsa) bands. We showed that G bands comprise two different subsets of bands, one of which is predominantly composed of L1 isochores, replicates at the end of the S phase, has a higher DNA compaction relative to H3+ bands and corresponds to the darkest G bands of Francke (1994). In contrast, the other subset is composed of L2 and H1 isochores, has less-extreme properties in replication and composition and corresponds to the less-dark G bands of Francke.
Indexed as
Identifiers
11196136What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.