ArticleMolecular pathology : MP2000
Imbalances of chromosome 17 in medulloblastomas determined by comparative genomic hybridisation and fluorescence in situ hybridisation.
Article in Molecular pathology : MP, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 47 citations in OpenAlex.
- Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial.Oncotarget · 2015Trial
- The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups.Cellular and molecular life sciences : CMLS · 2017Review
- Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.Cancer cell · 2015Article
- Mutation and expression analysis in medulloblastoma yields prognostic variants and a putative mechanism of disease for i17q tumors.Acta neuropathologica communications · 2014Article
- Early recurrence in standard-risk medulloblastoma patients with the common idic(17)(p11.2) rearrangement.Neuro-oncology · 2012Article
- Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma.Nature reviews. Cancer · 2010Review
- A pilot study of risk-adapted radiotherapy and chemotherapy in patients with supratentorial PNET.Neuro-oncology · 2009Article
- Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective.Neuro-oncology · 2008Review
- Genome wide copy number abnormalities in pediatric medulloblastomas as assessed by array comparative genome hybridization.Brain pathology (Zurich, Switzerland) · 2007Article
- Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8.BMC cancer · 2006Article
- High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors.Journal of neuropathology and experimental neurology · 2006Article
- Recent advances in embryonal tumours of the central nervous system.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2005Review
- Molecular pathogenesis of childhood brain tumors.Journal of neuro-oncology · 2004Review
- Genetic and expression profiles of cerebellar liponeurocytomas.Brain pathology (Zurich, Switzerland) · 2004Article
- Genetic abnormalities detected in ependymomas by comparative genomic hybridisation.British journal of cancer · 2002Article
- Clinical and molecular stratification of disease risk in medulloblastoma.British journal of cancer · 2001Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo investigate the status of chromosome 17 in a series of medulloblastomas using comparative genomic hybridisation (CGH) and fluorescence in situ hybridisation (FISH).
methodsFrozen tissue and formalin fixed, paraffin was embedded tissue from 27 medulloblastomas were analysed by CGH and FISH, respectively. CGH ratio profiles for chromosome 17 were compared with the results of FISH, for which loss or gain of 17p or 17q was assessed in two distinct ways using a combination of differentially labelled subtelomeric and centromeric probes and analysing 200 nuclei in each tumour.
resultsCGH revealed imbalances consistent with isochromosome 17q in eight of 27 tumours. Either loss of 17p or gain of 17q was identified in a further nine tumours, whereas 10 tumours were apparently balanced. Using control results from preparations of paraffin wax embedded tonsils, thresholds for the detection of abnormalities by FISH were established, either by determining the dominant pattern of signals in each case, or the mean ratio of subtelomeric to centromeric signals. Results by CGH and FISH were concordant in 21 of 27 tumours. In the remainder, most discrepancies related to methodological differences.
conclusionsCGH has a role in disclosing common, genome wide chromosomal gains or losses in tumours, the clinical relevance of which can then be studied in large archival series of paraffin wax embedded tumours using FISH.
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