ReviewCell stress & chaperones2000
Heat shock proteins: the fountainhead of innate and adaptive immune responses.
Review in Cell stress & chaperones, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Immunization of Mice with Gold Nanoparticles Conjugated to Thermostable Cancer Antigens Prevents the Development of Xenografted Tumors.International journal of molecular sciences · 2022Article
- Interaction of HSPA5 (Grp78, BIP) with negatively charged phospholipid membranes via oligomerization involving the N-terminal end domain.Cell stress & chaperones · 2020Article
- Assessing the oncolytic potential of rotavirus on mouse myeloma cell line Sp2/0-Ag14.Biomedica : revista del Instituto Nacional de Salud · 2020Article
- Antibodies to Heat Shock Proteins 90α and 90β in Psoriasis.Archivum immunologiae et therapiae experimentalis · 2020Article
- Endoplasmic Reticulum-Associated Degradation-Dependent Processing in Cross-Presentation and Its Potential for Dendritic Cell Vaccinations: A Review.Pharmaceutics · 2020Review
- Distinct Subcellular Compartments of Dendritic Cells Used for Cross-Presentation.International journal of molecular sciences · 2019Review
- Novel insights into the host immune response of chicken Harderian gland tissue during Newcastle disease virus infection and heat treatment.BMC veterinary research · 2018Article
- The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules.Annual review of immunology · 2017Review
- Liver transcriptome response to hyperthermic stress in three distinct chicken lines.BMC genomics · 2016Article
- Potential Response to Selection of HSP70 as a Component of Innate Immunity in the Abalone Haliotis rufescens.PloS one · 2015Article
- Bifidobacterium bifidum PRL2010 modulates the host innate immune response.Applied and environmental microbiology · 2014Article
- Gastroprotective activity of Annona muricata leaves against ethanol-induced gastric injury in rats via Hsp70/Bax involvement.Drug design, development and therapy · 2014Article
- Transcriptome analysis of silkworm, Bombyx mori, during early response to Beauveria bassiana challenges.PloS one · 2014Article
- Azacytidine induces necrosis of multiple myeloma cells through oxidative stress.Proteome science · 2013Article
- Article
- Secreted heat shock protein-90 (Hsp90) in wound healing and cancer.Biochimica et biophysica acta · 2012Review
- Down-regulation of HSP70 sensitizes gastric epithelial cells to apoptosis and growth retardation triggered by H. pylori.BMC gastroenterology · 2011Article
- Mechanisms of HSP72 release.Journal of biosciences · 2007Review
- Initiation of the Immune Response by Extracellular Hsp72: Chaperokine Activity of Hsp72.Current immunology reviews · 2006Article
- A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens.Journal of immune based therapies and vaccines · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of heat shock proteins to (1) chaperone peptides, including antigenic peptides; (2) interact with antigen-presenting cells through a receptor; (3) stimulate antigen-presenting cells to secrete inflammatory cytokines; and (4) mediate maturation of dendritic cells, makes them a unique starting point for generation of immune responses. These properties also permit the use of heat shock proteins for development of a new generation of prophylactic and therapeutic vaccines against cancers and infectious diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.