ArticleCell stress & chaperones2000
HSP70 peptidembearing and peptide-negative preparations act as chaperokines.
Article in Cell stress & chaperones, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 158 citations in OpenAlex.
- Role of heat shock protein and cytokine expression as markers of clinical outcomes with glutamine-supplemented parenteral nutrition in surgical ICU patients.Clinical nutrition (Edinburgh, Scotland) · 2020Trial
- Heat shock protein 70 promotes the progression of type 2 diabetic nephropathy by inhibiting T-cell immunoglobulin and mucin domain-3 and thereby promoting Th17/Treg imbalance.Nephrology (Carlton, Vic.) · 2024Article
- Chronic corticosterone exposure induces liver inflammation and fibrosis in association with mCell stress & chaperones · 2020Article
- Functioning of Mycobacterial Heat Shock Repressors Requires the Master Virulence Regulator PhoP.Journal of bacteriology · 2019Article
- Heat Shock Proteins as Immunomodulants.Molecules (Basel, Switzerland) · 2018Review
- Putative model for heat shock protein 70 complexation with receptor of advanced glycation end products through fluorescence proximity assays and normal mode analyses.Cell stress & chaperones · 2017Article
- The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management.Mediators of inflammation · 2015Review
- DAMPs activating innate and adaptive immune responses in COPD.Mucosal immunology · 2014Review
- Heat Shock Proteins: Intestinal Gatekeepers that Are Influenced by Dietary Components and the Gut Microbiota.Pathogens (Basel, Switzerland) · 2014Review
- Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells.PloS one · 2013Article
- IL-10 is significantly involved in HSP70-regulation of experimental subretinal fibrosis.PloS one · 2013Article
- A mouse model for triple-negative breast cancer tumor-initiating cells (TNBC-TICs) exhibits similar aggressive phenotype to the human disease.BMC cancer · 2012Article
- Pathology-dependent effects linked to small heat shock proteins expression: an update.Scientifica · 2012Review
- CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity.Autoimmune diseases · 2012Article
- The anti-inflammatory mechanisms of Hsp70.Frontiers in immunology · 2012Article
- Pediatric Sepsis - Part V: Extracellular Heat Shock Proteins: Alarmins for the Host Immune System.The open inflammation journal · 2011Article
- Article
- Rescuing of deficient killing and phagocytic activities of macrophages derived from non-obese diabetic mice by treatment with geldanamycin or heat shock: potential clinical implications.Cell stress & chaperones · 2011Article
- Identification of T-cell epitopes in Francisella tularensis using an ordered protein array of serological targets.Immunology · 2011Article
- Chronic inflammation in cancer development.Frontiers in immunology · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We recently elucidated a novel function for the 70-kDa heat shock protein (HSP70) as a chaperone and a cytokine, a chaperokine in human monocytes. Here we show that peptide-bearing and peptide-negative HSP70 preparations isolated from EMT6 mammary adenocarcinoma cells (EMT6-HSP70) act as chaperokines when admixed with murine splenocytes. EMT6-HSP70 bound with high affinity to the surface of splenocytes recovered from naive BALB/c mice. The [Ca2+]i inhibitor BAPTA dose dependently inhibited HSP70- but not LPS-induced NF-kappaB activity and subsequent augmentation of proinflammatory cytokine TNF-alpha, IL-1beta, and IL-6 production. Taken together, these results suggest that presence of peptide in the HSP70 preparation is not required for spontaneous activation of cells of the innate immune system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.