ArticleBMC developmental biology2001
High copy arrays containing a sequence upstream of mec-3 alter cell migration and axonal morphology in C. elegans.
Article in BMC developmental biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- IndividualLife science alliance · 2026Article
- Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.eLife · 2024Article
- Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.bioRxiv : the preprint server for biology · 2024Article
- Electrophysiological methods for Caenorhabditis elegans neurobiology.Methods in cell biology · 2012Article
- The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Antipsychotic drugs alter neuronal development including ALM neuroblast migration and PLM axonal outgrowth in Caenorhabditis elegans.International journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe Caenorhabditis elegans gene mec-3 encodes a LIM-homeodomain protein that is a master regulator of touch receptor neuron genes. Two of the touch neurons, the ALM neurons, are generated in the anterior of the animal and then migrate to near the middle of the animal. In animals transformed with a sequence upstream of mec-3, the ALM touch receptor neurons failed to migrate to their normal positions and sometimes migrated in the wrong direction, and the PLM touch receptor neurons showed axonal defects. Here we characterize this effect and identify the sequence causing the cell migration and axonal defects.
resultsThe ALM migration defect did not result from RNA interference (RNAi), nonspecific effects of carrying a transgenic array, expression of GFP, or the marker gene used to make the transformants. Instead, the ALM migration defect resulted from transgenic arrays containing many copies of a specific 104 bp DNA sequence. Transgenic arrays containing this sequence did not affect all cell migrations.
conclusionsThe mec-3 upstream sequence appeared to be sequestering (titrating out) a specific DNA-binding factor that is required for the ALMs to migrate correctly. Because titration of this factor could reverse the direction of ALM migrations, it may be part of a program that specifies both the direction and extent of ALM migrations. mec-3 is a master regulator of touch receptor neuron genes, so the factor or factors that bind this sequence may also be involved in specifying the fate of touch receptor neurons.
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