ArticleParasitology1975
Acquisition of host antigens by young Schistosoma mansoni in mice: correlation with failure to bind antibody in vitro.
Article in Parasitology, 1975. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 114 citations in OpenAlex.
- Binding of thyrotropin to selected Mycoplasma species: detection of serum antibodies against a specific Mycoplasma membrane antigen in patients with autoimmune thyroid disease.Journal of endocrinological investigation · 1989Article
- Surface antigens of Angiostrongylus cantonensis developing in permissive and non-permissive hosts.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1986Article
- The cercarial glycocalyx of Schistosoma mansoni.The Journal of cell biology · 1985Article
- Isolation of specific antigens from Angiostrongylus cantonensis. 1. Preparative flatbed isoelectric focusing.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1985Article
- Acquisition of host proteins by the tegument of Schistosoma mansoni recovered from rats.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1983Article
- Histopathological study of the attrition of challenge cercariae of Schistosoma mansoni in the skin of mice immunized by chronic infection and by use of highly X-irradiated cercariae.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1983Article
- Schistosomula of Schistosoma mansoni clear concanavalin A from their surface by sloughing.The Journal of cell biology · 1982Article
- KCl-Extractable surface antigens of Schistosoma mansoni: immunological characterization and applicability in immunodiagnosis.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1982Article
- Role of cell-generated hydrogen peroxide in granulocyte-mediated killing of schistosomula of Schistosoma mansoni in vitro.The Journal of clinical investigation · 1981Article
- Schistosomiasis: immunologic properties of developing schistosomula.The American journal of pathology · 1981Article
- Studies of the antibody-dependent killing of schistosomula of Schistosoma mansoni employing haptenic target antigens. I. Evidence that the loss in susceptibility to immune damage undergone by developing schistosomula involves a change unrelated to the masking of parasite antigens by host molecules.The Journal of experimental medicine · 1980Article
- Acquisition of murine major histocompatibility complex gene products by schistosomula of Schistosoma mansoni.The Journal of experimental medicine · 1978Article
- Blood flukes have a double outer membrane.Nature · 1977Article
- Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: damage by purieid eosinophils.The Journal of experimental medicine · 1977Article
- T-cell helper response to antigens of Schistosoma mansoni in CBA mice.Clinical and experimental immunology · 1976Article
- Acquisition of human blood group antigens by Schistosoma mansoni.Clinical and experimental immunology · 1976Article
- Eosinophil-enriched inflammatory response to schistosomula in the skin of mice immune to Schistosoma mansoni.The American journal of pathology · 1976Article
- Schistosoma mansoni in baboons. Antibody-dependent cell-mediated damage to 51Cr-labelled schistosomula.Clinical and experimental immunology · 1976Article
- [The immunology of schistosomiasis].Bulletin of the World Health Organization · 1976Review
- Immunology of schistosomiasis.Bulletin of the World Health Organization · 1974Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Young schistosomes collected after penetration through isolated mouse skin (3 h schistosomula) were cultured in medium containing immune rhesus monkey serum with a high titre of antibody known to kill schistosomula in the presence of complement. Morphological signs of damage in electron micrographs were confined to the surface tegument of the schistosomula. Antibodies in immune rhesus serum were shown to bind to the surface membrane of 3 h schistosomula using an antibody-enzyme bridge technique involving labelling with horseradish peroxidase and histochemical localization of the enzyme at the ultrastructural level. Schistosomula recovered from the lungs of mice 4 days after infection did not bind monkey antibodies at the surface and these 4-day schistosomula are not susceptible to damage by immune serum in vitro. Mouse erythrocyte antigens were detected on the surface of 4-day schistosomula using an appropriate antibody-enzyme bridge but these host antigens could not be found on 3 h schistosomula. This correlation between the presence of mouse host antigens on the surface of schistosomula and the inability of immune monkey antibodies to bind to the surface membrane is consistent with the hypothesis that host antigens are acquired by young schistosomes and serve to protect the surface membrane against antibody-mediated damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.