ArticleThe Journal of clinical investigation2001
Preferential suppression of CXCR4-specific strains of HIV-1 by antiviral therapy.
Article in The Journal of clinical investigation, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Deep-Sequencing Analysis of the Dynamics of HIV-1 Quasiespecies in Naive Patients during a Short Exposure to Maraviroc.Journal of virology · 2018Trial
- HIV-1 coreceptor switch during 2 years of structured treatment interruptions.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Trial
- Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir.Journal of virology · 2006Trial
- Evolution of human immunodeficiency virus type 1 coreceptor usage during antiretroviral Therapy: a Bayesian approach.Journal of virology · 2004Trial
- Treatment of advanced human immunodeficiency virus type 1 disease with the viral entry inhibitor PRO 542.Antimicrobial agents and chemotherapy · 2004Trial
- Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas.Frontiers of medicine · 2018Review
- A genotypic method for determining HIV-2 coreceptor usage enables epidemiological studies and clinical decision support.Retrovirology · 2016Article
- X4 viruses are frequently archived in patients with long-term HIV infection but do not seem to influence the "inflamm-aging" process.BMC infectious diseases · 2013Article
- Natural Scrub Typhus Antibody Suppresses HIV CXCR4(X4) Viruses.Infectious disease reports · 2013Review
- A novel denaturing heteroduplex tracking assay for genotypic prediction of HIV-1 tropism.Journal of virological methods · 2012Article
- Predicted HIV-1 coreceptor usage among Kenya patients shows a high tendency for subtype d to be cxcr4 tropic.AIDS research and therapy · 2012Article
- Evolution of proviral DNA HIV-1 tropism under selective pressure of maraviroc-based therapy.The Journal of antimicrobial chemotherapy · 2012Article
- Persistence and emergence of X4 virus in HIV infection.Mathematical biosciences and engineering : MBE · 2011Article
- Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases.PLoS pathogens · 2011Article
- Clinical significance of HIV-1 coreceptor usage.Journal of translational medicine · 2011Review
- Co-receptor usage and prediction of V3 genotyping algorithms in HIV-1 subtype B' from paid blood donors experienced anti-retroviral therapy in Chinese central province.Virology journal · 2010Article
- Evolution and recombination of genes encoding HIV-1 drug resistance and tropism during antiretroviral therapy.Virology · 2010Article
- Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection.PLoS computational biology · 2009Article
- Major coexisting human immunodeficiency virus type 1 env gene subpopulations in the peripheral blood are produced by cells with similar turnover rates and show little evidence of genetic compartmentalization.Journal of virology · 2009Article
- Genomic analysis of HIV type 1 strains derived from a mother and child pair of long-term nonprogressors.AIDS research and human retroviruses · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
To initiate infection, HIV-1 requires a primary receptor, CD4, and a secondary receptor, principally the chemokine receptor CCR5 or CXCR4. Coreceptor usage plays a critical role in HIV-1 disease progression. HIV-1 transmitted in vivo generally uses CCR5 (R5), but later CXCR4 (X4) strains may emerge; this shift heralds CD4+ cell depletion and clinical deterioration. We asked whether antiretroviral therapy can shift HIV-1 populations back to R5 viruses after X4 strains have emerged, in part because treatment has been successful in slowing disease progression without uniformly suppressing plasma viremia. We analyzed the coreceptor usage of serial primary isolates from 15 women with advanced disease who demonstrated X4 viruses. Coreceptor usage was determined by using a HOS-CD4+ cell system, biological and molecular cloning, and sequencing the envelope gene V3 region. By constructing a mathematical model to measure the proportion of virus in a specimen using each coreceptor, we demonstrated that the predominant viral population shifted from X4 at baseline to R5 strains after treatment. Multivariate analyses showed that the shift was independent of changes in plasma HIV-1 RNA level and CD4+ cell count. Hence, combination therapy may lead to a change in phenotypic character as well as in the quantity of HIV-1. Shifts in coreceptor usage may thereby contribute to the clinical efficacy of anti-HIV drugs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.