ArticleAntimicrobial agents and chemotherapy2001
Phenotypic resistance of Staphylococcus aureus, selected Enterobacteriaceae, and Pseudomonas aeruginosa after single and multiple in vitro exposures to ciprofloxacin, levofloxacin, and trovafloxacin.
Article in Antimicrobial agents and chemotherapy, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- The magnitude of the association between fluoroquinolone use and quinolone-resistant Escherichia coli and Klebsiella pneumoniae may be lower than previously reported.Antimicrobial agents and chemotherapy · 2004Pooled it
- Fluoroquinolone-resistant uncomplicated urinary tract infections, Chinese herbal medicine may provide help.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2011Trial
- Molecular characterization and differential effects of levofloxacin and ciprofloxacin on the potential for developing quinolone resistance among clinicalFrontiers in microbiology · 2023Article
- Comparative Studies to Uncover Mechanisms of Action ofACS infectious diseases · 2022Article
- UVC-LED-based face mask design and efficacy against common germs.Arhiv za higijenu rada i toksikologiju · 2022Article
- Potent, specific MEPicides for treatment of zoonotic staphylococci.PLoS pathogens · 2020Article
- Bacteriological profiling of diphenylureas as a novel class of antibiotics against methicillin-resistant Staphylococcus aureus.PloS one · 2017Article
- Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.Clinical microbiology reviews · 2015Review
- No decrease in susceptibility to NVC-422 in multiple-passage studies with methicillin-resistant Staphylococcus aureus, S. aureus, Pseudomonas aeruginosa, and Escherichia coli.Antimicrobial agents and chemotherapy · 2012Article
- Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction.PloS one · 2012Article
- The anti-methicillin-resistant Staphylococcus aureus quinolone WCK 771 has potent activity against sequentially selected mutants, has a narrow mutant selection window against quinolone-resistant Staphylococcus aureus, and preferentially targets DNA gyrase.Antimicrobial agents and chemotherapy · 2006Article
- Using interrupted time series analysis to assess associations of fluoroquinolone formulary changes with susceptibility of gram-negative pathogens and isolation rates of methicillin-resistant Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2006Article
- Pseudomonas aeruginosa, Staphylococcus aureus, and fluoroquinolone use.Emerging infectious diseases · 2005Article
- Pharmacodynamic modeling of the evolution of levofloxacin resistance in Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2005Article
- Pharmacodynamic modeling of ciprofloxacin resistance in Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2005Article
- Evolution of ciprofloxacin-resistant Staphylococcus aureus in in vitro pharmacokinetic environments.Antimicrobial agents and chemotherapy · 2004Article
- BpeAB-OprB, a multidrug efflux pump in Burkholderia pseudomallei.Antimicrobial agents and chemotherapy · 2004Article
- Maintaining fluoroquinolone class efficacy: review of influencing factors.Emerging infectious diseases · 2003Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phenotypic resistance of selected organisms to ciprofloxacin, levofloxacin, and trovafloxacin was defined as a MIC of > or =4 microg/ml. The dynamics of resistance were studied after single and sequential drug exposures: clinical isolates of methicillin-susceptible and methicillin-resistant Staphylococcus aureus (MSSA and MRSA), Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, and Pseudomonas aeruginosa were utilized. After a single 48-h exposure of a large inoculum to four times the initial MIC for the organism, the frequency of selection of resistant mutants of MSSA was greater for trovafloxacin than levofloxacin (P = 0.008); for E. cloacae, the frequency was highest for ciprofloxacin and lowest for levofloxacin and trovafloxacin; for S. marcescens, the frequency was highest for trovafloxacin and lowest for ciprofloxacin (P = 0.003). The results of serial passage experiments were analyzed both by the Kaplan-Meier product-limited method as well as by analysis of variance of mean inhibitory values. By both methods, MSSA and MRSA expressed mutants resistant to ciprofloxacin after fewer passages than were required for either levofloxacin or trovafloxacin. For the aerobic gram-negative bacilli, two general patterns emerged. Mutants resistant to trovafloxacin appeared sooner and reached higher mean MICs than did mutants resistant to levofloxacin or ciprofloxacin. Mutants resistant to ciprofloxacin appeared later and reached mean MICs lower than the MICs of the other two drugs studied. Even though individual strain variation occurred, the mean MICs were reproduced when the serial passage experiment was repeated using an identical panel of E. coli isolates. In summary, the dynamic selection of fluoroquinolone-resistant bacteria can be demonstrated in experiments that employ serial passage of bacteria in vitro.
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