ArticleInfection and immunity2001
Aberrant macrophage and neutrophil population dynamics and impaired Th1 response to Listeria monocytogenes in colony-stimulating factor 1-deficient mice.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Pivotal role ofFrontiers in medicine · 2024Review
- Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor).Journal for immunotherapy of cancer · 2023Article
- Identification and evaluation of a panel of strong constitutive promoters in Listeria monocytogenes for improving the expression of foreign antigens.Applied microbiology and biotechnology · 2021Article
- Clinical Development of Colony-Stimulating Factor 1 Receptor (CSF1R) Inhibitors.Journal of immunotherapy and precision oncology · 2021Review
- Targeting both tumour-associated CXCR2Gut · 2018Article
- Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.Cancer cell · 2017Article
- Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota.Scientific reports · 2017Article
- Effects of Lipopolysaccharide on Human First Trimester Villous Cytotrophoblast Cell Function In Vitro.Biology of reproduction · 2016Article
- CSF-1R signaling in health and disease: a focus on the mammary gland.Journal of mammary gland biology and neoplasia · 2014Review
- From mice to women: the conundrum of immunity to infection during pregnancy.Journal of reproductive immunology · 2013Review
- Article
- Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes.Scientific reports · 2012Article
- Immunomodulatory Effects of Danshen (Salvia miltiorrhiza) in BALB/c Mice.ISRN inflammation · 2012Article
- Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1.The Journal of experimental medicine · 2011Article
- Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits.PloS one · 2011Article
- Trophic macrophages in development and disease.Nature reviews. Immunology · 2009Review
- The bradykinin B2 receptor in the early immune response against Listeria infection.Medical microbiology and immunology · 2009Article
- Colony-stimulating factor-1-dependent macrophage functions regulate the maternal decidua immune responses against Listeria monocytogenes infections during early gestation in mice.Infection and immunity · 2009Article
- Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response.Neoplasia (New York, N.Y.) · 2008Article
- Innate and adaptive immune responses to Listeria monocytogenes: a short overview.Microbes and infection · 2007Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Listeria monocytogenes, a facultative intracellular bacterium, has been used extensively to study innate immune responses. Macrophages act as hosts for this bacterium as well as a major defense against it. Using mice homozygous for a null mutation (Csf1(op)) in the gene for the mononuclear phagocytic growth factor colony-stimulating factor 1 (CSF-1), we have demonstrated that CSF-1-regulated macrophages were essential to defend against a listerial infection. In the absence of CSF-1, monocytes were not recruited to the sites of infection due to the lack of synthesis of the macrophage chemoattractant chemokine MCP-1. In addition, there was no burst of interleukin-10 (IL-10) synthesis that has been shown to result in the egress of neutrophils from sites of infection. Consequently, neutrophils were not replaced by macrophages, and numerous neutrophil-filled microabscesses developed, followed by tissue destruction and death of the mice. In the CSF-1 nullizygous mice compared to wild-type mice, there was also a very low synthesis of gamma interferon (IFN-gamma), resulting in reduced macrophage activation. However, the concentrations of the IFN-gamma-inducing cytokines IL-12 and IL-18 at this bacterial load were similar in these mutant mice. In contrast, IL-6 concentrations were dramatically reduced. Administration of IL-6 to Csf1(op)/Csf1(op) mice significantly increased the synthesis of IFN-gamma and reduced the bacterial burden to a greater extent than treatment with IFN-gamma alone. These data indicate that IL-6 occupies a central role in the CSF-1-regulated macrophage response to L. monocytogenes.
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