ArticleInfection and immunity2001
Two epitopes shared by Taenia crassiceps and Taenia solium confer protection against murine T. crassiceps cysticercosis along with a prominent T1 response.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 76 citations in OpenAlex.
- Immunomodulatory effects of nematode-microbiota interactions in cancer therapy.Frontiers in immunology · 2026Review
- Innate Immune Response to Helminth Infections.Advances in experimental medicine and biology · 2025Review
- Differential Protein Expression ofPathogens (Basel, Switzerland) · 2023Article
- Sexual Dimorphism of the Neuroimmunoendocrine Response in the Spleen during a Helminth Infection: A New Role for an Old Player?Pathogens (Basel, Switzerland) · 2022Article
- The Genomes of Two Strains ofFrontiers in cellular and infection microbiology · 2022Article
- Mimotope-based antigens as potential vaccine candidates in experimental murine cysticercosis.Parasitology · 2020Article
- Article
- Anti-GK1 antibodies damage Taenia crassiceps cysticerci through complement activation.Parasitology research · 2018Article
- Article
- Article
- Sequence analysis and molecular characterization of Wnt4 gene in metacestodes of Taenia solium.The Korean journal of parasitology · 2014Article
- A review on diagnostic and preventive aspects of cystic echinococcosis and human cysticercosis.Tropical parasitology · 2012Article
- Heterologous prime-boost oral immunization with GK-1 peptide from Taenia crassiceps cysticerci induces protective immunity.Clinical and vaccine immunology : CVI · 2011Article
- Cestode antigens induce a tolerogenic-like phenotype and inhibit LPS inflammatory responses in human dendritic cells.International journal of biological sciences · 2011Article
- Characterization of S3Pvac anti-cysticercosis vaccine components: implications for the development of an anti-cestodiasis vaccine.PloS one · 2010Article
- A STAT4-dependent Th1 response is required for resistance to the helminth parasite Taenia crassiceps.Infection and immunity · 2004Article
- Isolated intramuscular cysticercosis: Clinicopathological features, diagnosis and management - A review.Journal of clinical orthopaedics and traumaReview
- Fact or hypothesis: Taenia crassiceps as a model for Taenia solium, and the S3Pvac vaccine.Parasite immunologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taenia crassiceps recombinant antigens KETc1 and KETc12 have been shown to induce high level of protection against experimental murine T. crassiceps cysticercosis, an experimental model successfully used to test candidate antigens for use in vaccination against porcine Taenia solium cysticercosis. Based on the deduced amino acid sequence, KETc1 and KETc12 were chemically synthesized in linear form. Immunization with KETc1 induced 66.7 to 100% protection against murine cysticercosis, and immunization with KETc12 induced 52.7 to 88.1% protection. The elicited immune response indicated that both peptides contain at least one B-cell epitope (as demonstrated by their ability to induce specific antibodies) and one T-cell epitope that strongly stimulated the proliferation of T cells primed with either the free peptide or total cysticercal T. crassiceps antigens. The high percentage of spleen cells expressing inflammatory cytokines points to the likelihood of a T1 response being involved in protection. The protective capacity of the peptides and their presence in all developmental stages of T. solium point to these two epitopes as strong candidates for inclusion in a polyepitopic synthetic vaccine against T. solium pig cysticercosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.