ArticleInfection and immunity2001
Cysteine protease secreted by Paragonimus westermani attenuates effector functions of human eosinophils stimulated with immunoglobulin G.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- A comprehensive mechanistic multicellular model of the human immune system spanning 11 diseases.Frontiers in immunology · 2026Article
- Catalytically Active Recombinant Cysteine Proteases ofInternational journal of molecular sciences · 2025Article
- Paragonimiasis.Advances in experimental medicine and biology · 2024Review
- Review
- Examining human paragonimiasis as a differential diagnosis to tuberculosis in The Gambia.BMC research notes · 2018Article
- Molecular and immunological characterization of cathepsin L-like cysteine protease of Paragonimus pseudoheterotremus.Parasitology research · 2016Article
- Ten Weeks of Infection with a Tissue-Invasive Helminth Protects against Local Immune Complex-Mediated Inflammation, but Not Cutaneous Type I Hypersensitivity, in Previously Sensitized Mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Cryptosporidium pathogenicity and virulence.Clinical microbiology reviews · 2013Review
- How pathogen-derived cysteine proteases modulate host immune responses.Advances in experimental medicine and biology · 2011Review
- Immunodominant antigens in Naegleria fowleri excretory--secretory proteins were potential pathogenic factors.Parasitology research · 2009Article
- Eosinophil-mediated tissue inflammatory responses in helminth infection.The Korean journal of parasitology · 2009Review
- North American paragonimiasis (Caused by Paragonimus kellicotti) in the context of global paragonimiasis.Clinical microbiology reviews · 2009Review
- A 27 kDa cysteine protease secreted by newly excysted Paragonimus westermani metacercariae induces superoxide anion production and degranulation of human eosinophils.The Korean journal of parasitology · 2008Article
- Degranulation of human eosinophils induced by Paragonimus westermani-secreted protease.The Korean journal of parasitology · 2005Article
- A cysteine protease from Taenia solium metacestodes induce apoptosis in human CD4+ T-cells.Parasitology research · 2004Article
- Extracellular enzymes with immunomodulating activities: variations on a theme in Streptococcus pyogenes.Infection and immunity · 2003Review
- EndoS and SpeB from Streptococcus pyogenes inhibit immunoglobulin-mediated opsonophagocytosis.Infection and immunity · 2002Article
- Excretory bladder: the source of cysteine proteases in Paragonimus westermani metacercariae.The Korean journal of parasitology · 2002Article
- Effect of SpeB and EndoS from Streptococcus pyogenes on human immunoglobulins.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An immunoglobulin G (IgG)-coated surface, such as that found on helminth parasites, is one of the most effective physiologic stimuli for eosinophil activation. The cysteine proteases secreted by tissue-invasive helminth larvae play an important role in evasion of the immune response by degrading the host immunoglobulins. In this study, we investigated whether cysteine proteases in the excretory-secretory product (ESP) produced by Paragonimus westermani newly excysted metacercariae (PwNEM), which cause pulmonary or extrapulmonary paragonimiasis in human beings, could modify effector functions of human eosinophils stimulated with IgG. We coated 96-well plates with human IgG in the absence or presence of the ESP produced by PwNEM. When eosinophils were incubated in the wells coated with IgG in the presence of the ESP, eosinophil degranulation and superoxide production were significantly reduced compared with results for cells incubated in wells coated with IgG alone. This inhibitory effect of the ESP on IgG-induced superoxide production was dose dependent and was significantly abolished by pretreatment of the ESP with heat. These findings suggest that the cysteine proteases secreted by PwNEM attenuate both activation and degranulation of eosinophils stimulated with IgG. Thus, the cysteine proteases produced by tissue-invasive helminth larvae play crucial roles in evasion of IgG-dependent eosinophil helminthotoxicity and in reduction of eosinophil-associated tissue inflammation during the migratory period.
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