ArticleInfection and immunity2001
Interleukin-12 promotes pathologic liver changes and death in mice coinfected with Schistosoma mansoni and Toxoplasma gondii.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Immunocytokines in cancer: a safety perspective.Frontiers in immunology · 2026Review
- Beyond schistosomiasis: unraveling co-infections and altered immunity.Clinical microbiology reviews · 2024Review
- Intestinal helminth infection enhances bacteria-induced recruitment of neutrophils to the airspace.Scientific reports · 2019Article
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- Interleukins in chronic liver disease: lessons learned from experimental mouse models.Clinical and experimental gastroenterology · 2014Review
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- IL-12Rβ2 is critical for survival of primary Francisella tularensis LVS infection.Journal of leukocyte biology · 2013Article
- Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Helminth coinfection does not affect therapeutic effect of a DNA vaccine in mice harboring tuberculosis.PLoS neglected tropical diseases · 2010Article
- Article
- Coinfection with the intestinal nematode Heligmosomoides polygyrus markedly reduces hepatic egg-induced immunopathology and proinflammatory cytokines in mouse models of severe schistosomiasis.Infection and immunity · 2008Article
- Adjuvant formulations possess differing efficacy in the potentiation of antibody and cell mediated responses to a human malaria vaccine under selective immune genes knockout environment.International immunopharmacology · 2008Article
- BALB/c mice resistant to Toxoplasma gondii infection proved to be highly susceptible when previously infected with Myocoptes musculinus fur mites.International journal of experimental pathology · 2007Article
- Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Article
- Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice.Infection and immunity · 2005Article
- Infection with Toxoplasma gondii reduces established and developing Th2 responses induced by Nippostrongylus brasiliensis infection.Infection and immunity · 2004Article
- Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The immunomodulatory effects of rolipram abolish drug-resistant latent phase ofJournal of microscopy and ultrastructureArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
We previously demonstrated that mice concurrently infected with Schistosoma mansoni and Toxoplasma gondii undergo accelerated mortality which is preceded by severe liver damage. Abnormally high levels of serum tumor necrosis factor alpha (TNF-alpha) in the dually infected mice suggested a role for this and related proinflammatory mediators in the pathologic alterations. In order to evaluate the factors involved in increased inflammatory-mediator production and mortality, interleukin-12(-/-) (IL-12(-/-)) mice were coinfected with S. mansoni and T. gondii, and survival and immune responses were monitored. These IL-12(-/-) mice displayed decreased liver damage and prolonged time to death relative to wild-type animals also coinfected with these parasites. Relative to the response of cells from the coinfected wild-type animals, levels of TNF-alpha, gamma interferon, and NO produced by splenocytes from coinfected IL-12(-/-) mice were reduced, and levels of IL-5 and IL-10 were increased, with the net result that the immune response of the dually infected IL-12(-/-) mice was similar to that of the wild-type mice infected with S. mansoni alone. While dually infected wild-type animals succumb in the absence of overt parasitemia, the delayed death in the absence of IL-12 is associated with relatively uncontrolled T. gondii replication. These data support the view that S. mansoni-infected mice are acutely sensitive to infection with T. gondii as a result of their increased hepatic sensitivity to high levels of proinflammatory cytokines; IL-12 and TNF-alpha are implicated in this process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.