ArticleAmerican journal of human genetics2001
Patterns of ancestral human diversity: an analysis of Alu-insertion and restriction-site polymorphisms.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 168 citations in OpenAlex.
- Structural Variations of Alu Elements in the Kuwaiti Population: Laying the Foundations for Forensic Medicine.Annals of human genetics · 2026Article
- Genetic Polymorphism RevealsAnimals : an open access journal from MDPI · 2025Article
- Ancestral alleles defined for 70 million cattle variants using a population-based likelihood ratio test.Genetics, selection, evolution : GSE · 2024Article
- Recent advances and current challenges in population genomics of structural variation in animals and plants.Frontiers in genetics · 2022Review
- Haplotypic Associations and Differentiation of MHC Class II Polymorphic Alu Insertions at Five Loci With HLA-DRB1 Alleles in 12 Minority Ethnic Populations in China.Frontiers in genetics · 2021Article
- Article
- Analysis of lineage-specificMobile DNA · 2018Article
- Genetic differentiation and population structure of five ethnic groups of Punjab (North-West India).Molecular genetics and genomics : MGG · 2016Article
- Development of Novel High-Resolution Melting-Based Assays for Genotyping Two Alu Insertion Polymorphisms (FXIIIB and PV92).Molecular biotechnology · 2016Article
- Polymorphic Alu Insertion/Deletion in Different Caste and Tribal Populations from South India.PloS one · 2016Article
- Read count-based method for high-throughput allelic genotyping of transposable elements and structural variants.BMC genomics · 2015Article
- Evaluating intra- and inter-individual variation in the human placental transcriptome.Genome biology · 2015Article
- Association and differentiation of MHC class I and II polymorphic Alu insertions and HLA-A, -B, -C and -DRB1 alleles in the Chinese Han population.Molecular genetics and genomics : MGG · 2014Article
- Distinct mutational behaviors differentiate short tandem repeats from microsatellites in the human genome.Genome biology and evolution · 2013Article
- EWS/FLI-responsive GGAA microsatellites exhibit polymorphic differences between European and African populations.Cancer genetics · 2012Article
- Comparative use of InDel and SSR markers in deciphering the interspecific structure of cultivated citrus genetic diversity: a perspective for genetic association studies.Molecular genetics and genomics : MGG · 2012Article
- Alu mobile elements: from junk DNA to genomic gems.Scientifica · 2012Review
- APOE, MTHFR, LDLR and ACE polymorphisms among Angami and Lotha Naga populations of Nagaland, India.Journal of community health · 2011Article
- Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans.Human mutation · 2011Article
- What is a microsatellite: a computational and experimental definition based upon repeat mutational behavior at A/T and GT/AC repeats.Genome biology and evolution · 2010Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
We have analyzed 35 widely distributed, polymorphic Alu loci in 715 individuals from 31 world populations. The average frequency of Alu insertions (the derived state) is lowest in Africa (.42) but is higher and similar in India (.55), Europe (.56), and Asia (.57). A comparison with 30 restriction-site polymorphisms (RSPs) for which the ancestral state has been determined shows that the frequency of derived RSP alleles is also lower in Africa (.35) than it is in Asia (.45) and in Europe (.46). Neighbor-joining networks based on Alu insertions or RSPs are rooted in Africa and show African populations as separate from other populations, with high statistical support. Correlations between genetic distances based on Alu and nuclear RSPs, short tandem-repeat polymorphisms, and mtDNA, in the same individuals, are high and significant. For the 35 loci, Alu gene diversity and the diversity attributable to population subdivision is highest in Africa but is lower and similar in Europe and Asia. The distribution of ancestral alleles is consistent with an origin of early modern human populations in sub-Saharan Africa, the isolation and preservation of ancestral alleles within Africa, and an expansion out of Africa into Eurasia. This expansion is characterized by increasing frequencies of Alu inserts and by derived RSP alleles with reduced genetic diversity in non-African populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.