ArticleArthritis research2001
The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8).
Article in Arthritis research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 106 citations in OpenAlex.
- Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritis.Annals of the rheumatic diseases · 2003Trial
- Reduced CCL/Be-specific CD4+ T cells in CCL3-deficient or peptide-MHCII CAR-T cell-treated mice.JCI insight · 2026Article
- Serum interleukin-8 levels relate to disease activity in patients with rheumatoid arthritis.Therapeutic advances in musculoskeletal disease · 2026Article
- The forgotten key players in rheumatoid arthritis: IL-8 and IL-17 - Unmet needs and therapeutic perspectives.Frontiers in medicine · 2023Review
- Chemokines and chemokine receptors as promising targets in rheumatoid arthritis.Frontiers in immunology · 2023Review
- The chemokine landscape: one system multiple shades.Frontiers in immunology · 2023Review
- [Effect of chemokines CXCL9 and CXCL10 on bone erosion in patients with rheumatoid arthritis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- D-Lactate Increases Cytokine Production in Bovine Fibroblast-Like Synoviocytes via MCT1 Uptake and the MAPK, PI3K/Akt, and NFκB Pathways.Animals : an open access journal from MDPI · 2020Article
- Data describing expression of formyl peptide receptor 2 in human articular chondrocytes.Data in brief · 2020Article
- Functional Deficits in Mice Expressing Human Interleukin 8.Comparative medicine · 2020Article
- Article
- Recombinant Adiponectin Induces the Production of Pro-Inflammatory Chemokines and Cytokines in Circulating Mononuclear Cells and Fibroblast-Like Synoviocytes From Non-Inflamed Subjects.Frontiers in immunology · 2020Article
- Comprehensive Bioinformatics Analysis Reveals Hub Genes and Inflammation State of Rheumatoid Arthritis.BioMed research international · 2020Article
- Chemokines in rheumatic diseases: pathogenic role and therapeutic implications.Nature reviews. Rheumatology · 2019Review
- Immunoexpression of canonical Wnt and NF-κB signaling pathways in the temporomandibular joint of arthritic rats.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Article
- Article
- RHAMM induces progression of rheumatoid arthritis by enhancing the functions of fibroblast-like synoviocytes.BMC musculoskeletal disorders · 2018Article
- Immunomodulatory drug methotrexate used to treat patients with chronic inflammatory rheumatisms post-chikungunya does not impair the synovial antiviral and bone repair responses.PLoS neglected tropical diseases · 2018Article
- Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis.Arthritis research & therapy · 2017Article
- Synovial tissue research: a state-of-the-art review.Nature reviews. Rheumatology · 2017Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Paired synovial tissue samples were obtained from both clinically uninvolved (CU) and clinically involved (CI) knee joints of eight rheumatoid arthritis (RA) patients. In addition, biopsies were taken from five control subjects. We observed the expression of the chemokines CXCL8, CXCL9, CXCL10, CCL2 and CCL4 in CI and CU joints of RA patients. In particular, CXCL8 protein levels were specifically increased in CI joints compared with CU joints, which was confirmed by immunohistochemistry and in situ hybridization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.