ArticleBMC genetics2001
Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice.
Article in BMC genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 90 citations in OpenAlex.
- Systemic Treatment with Nicotinamide Riboside Is Protective in Two Mouse Models of Retinal Ganglion Cell Damage.Pharmaceutics · 2021Article
- The Retinal Ganglion Cell Response to Blast-Mediated Traumatic Brain Injury Is Genetic Background Dependent.Investigative ophthalmology & visual science · 2021Article
- Changes of Ocular Dimensions as a Marker of Disease Progression in a Murine Model of Pigmentary Glaucoma.Frontiers in pharmacology · 2020Article
- Translational Preclinical Pharmacologic Disease Models for Ophthalmic Drug Development.Pharmaceutical research · 2019Review
- Nonproliferative and Proliferative Lesions of the Ratand Mouse Special Sense Organs(Ocular [eye and glands], Olfactory and Otic).Journal of toxicologic pathology · 2018Review
- Genetic modifiers as relevant biological variables of eye disorders.Human molecular genetics · 2017Review
- YBR/EiJ mice: a new model of glaucoma caused by genes on chromosomes 4 and 17.Disease models & mechanisms · 2016Article
- Characterization of intraocular pressure pattern and changes of retinal ganglion cells in DBA2J glaucoma mice.International journal of ophthalmology · 2016Article
- Mutation in Osteoactivin Promotes Receptor Activator of NFκB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function.The Journal of biological chemistry · 2015Article
- Genetic modifiers and oligogenic inheritance.Cold Spring Harbor perspectives in medicine · 2015Review
- Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro.The American journal of pathology · 2014Article
- Central corneal thickness does not correlate with TonoLab-measured IOP in several mouse strains with single transgenic mutations of matricellular proteins.Experimental eye research · 2013Article
- Article
- Generating embryonic stem cells from the inbred mouse strain DBA/2J, a model of glaucoma and other complex diseases.PloS one · 2012Article
- Comparison of bone morphogenetic protein-2 and osteoactivin for mesenchymal cell differentiation: effects of bolus and continuous administration.Journal of cellular physiology · 2011Article
- Anterior segment dysgenesis and early-onset glaucoma in nee mice with mutation of Sh3pxd2b.Investigative ophthalmology & visual science · 2011Article
- Manganese-enhanced MRI of the DBA/2J mouse model of hereditary glaucoma.Investigative ophthalmology & visual science · 2008Article
- Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.Pigment cell & melanoma research · 2008Article
- Alterations of amino acids and glutamate transport in the DBA/2J mouse retina; possible clues to degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2007Article
- Vascular changes in the posterior eye segment of secondary angle-closure glaucoma: cause or consequence?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2006Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundGlaucoma is a common disease but its molecular etiology is poorly understood. It involves retinal ganglion cell death and optic nerve damage that is often associated with elevated intraocular pressure. Identifying genes that modify glaucoma associated phenotypes is likely to provide insights to mechanisms of glaucoma. We previously reported glaucoma in DBA/2J mice caused by recessive alleles at two loci, isa and ipd, that cause iris stromal atrophy and iris pigment dispersion, respectively. A approach for identifying modifier genes is to study the effects of specific mutations in different mouse strains. When the phenotypic effect of a mutation is modified upon its introduction into a new strain, crosses between the parental strains can be used to identify modifier genes. The purpose of this study was to determine if the effects of the DBA/2J derived isa and ipd loci are modified in strain AKXD-28/Ty.
resultsAKXD-28/Ty mice develop glaucoma characterized by intraocular pressure elevation, retinal ganglion loss, and optic nerve excavation. In AKXD-28/Ty, isa causes an iris stromal atrophy phenotype as in DBA/2J. However, the iris pigment dispersion phenotype associated with ipd in DBA/2J does not occur in AKXD-28/Ty. Additionally, a greater severity and speed of retinal and optic nerve damage following intraocular pressure elevation in AKXD-28/Ty compared to DBA/2J mice suggests that AKXD-28/Ty is more susceptible to pressure-induced cell death.
conclusionsThe consequences of the ipd and isa mutations are modified in the AKXD-28/Ty background. These strains provide a resource for the identification of modifier genes that modulate pigment dispersion and susceptibility to pressure-induced cell death.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.