ArticleBMC developmental biology2001
Dynamic expression of a glutamate decarboxylase gene in multiple non-neural tissues during mouse development.
Article in BMC developmental biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 68 citations in OpenAlex.
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- Deficient or Excess Folic Acid Supply During Pregnancy Alter Cortical Neurodevelopment in Mouse Offspring.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Early-infantile onset epilepsy and developmental delay caused by bi-allelic GAD1 variants.Brain : a journal of neurology · 2020Article
- Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration.Frontiers in cell and developmental biology · 2020Article
- Neural differentiation, selection and transcriptomic profiling of human neuromesodermal progenitor-like cellsDevelopment (Cambridge, England) · 2018Article
- Mesomere-derived glutamate decarboxylase-expressing blastocoelar mesenchyme cells of sea urchin larvae.Biology open · 2014Article
- Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.BMC cancer · 2013Article
- Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice.Neural development · 2012Article
- Whole mount in situ hybridization of E8.5 to E11.5 mouse embryos.Journal of visualized experiments : JoVE · 2011Article
- Article
- Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development.Journal of neurodevelopmental disorders · 2010Article
- A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development.PLoS biology · 2004Article
- Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart.BMC developmental biology · 2003Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlutamate decarboxylase (GAD) is the biosynthetic enzyme for the neurotransmitter gamma-aminobutyric acid (GABA). Mouse embryos lacking the 67-kDa isoform of GAD (encoded by the Gad1 gene) develop a complete cleft of the secondary palate. This phenotype suggests that this gene may be involved in the normal development of tissues outside of the CNS. Although Gad1 expression in adult non-CNS tissues has been noted previously, no systematic analysis of its embryonic expression outside of the nervous system has been performed. The objective of this study was to define additional structures outside of the central nervous system that express Gad1, indicating those structures that may require its function for normal development.
resultsOur analysis detected the localized expression of Gad1 transcripts in several developing tissues in the mouse embryo from E9.0-E14.5. Tissues expressing Gad1 included the tail bud mesenchyme, the pharyngeal pouches and arches, the ectodermal placodes of the developing vibrissae, and the apical ectodermal ridge (AER), mesenchyme and ectoderm of the limb buds.
conclusionsSome of the sites of Gad1 expression are tissues that emit signals required for patterning and differentiation (AER, vibrissal placodes). Other sites correspond to proliferating stem cell populations that give rise to multiple differentiated tissues (tail bud mesenchyme, pharyngeal endoderm and mesenchyme). The dynamic expression of Gad1 in such tissues suggests a wider role for GABA signaling in development than was previously appreciated.
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