ArticleAnnals of surgery2001
Norepinephrine modulates myelopoiesis after experimental thermal injury with sepsis.
Article in Annals of surgery, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Neuroimmune Interactions and Their Role in Immune Cell Trafficking in Cardiovascular Diseases and Cancer.International journal of molecular sciences · 2025Review
- Made to order: emergency myelopoiesis and demand-adapted innate immune cell production.Nature reviews. Immunology · 2024Review
- Spinal cord injury causes chronic bone marrow failure.Nature communications · 2020Article
- Adrenergic Modulation of Hematopoiesis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020Review
- Effects of dermal wounding on distal primary tumor immunobiology in mice.The Journal of surgical research · 2018Article
- Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult.Current opinion in hematology · 2018Review
- Myelo-erythroid commitment after burn injury is under β-adrenergic control via MafB regulation.American journal of physiology. Cell physiology · 2017Article
- Neuroendocrine regulation of inflammation.Seminars in immunology · 2014Review
- Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Perturbed mononuclear phagocyte system in severely burned and septic patients.Shock (Augusta, Ga.) · 2013Review
- Noradrenergic neurons regulate monocyte trafficking and mortality during gram-negative peritonitis in mice.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Article
- Molecular pathways: beta-adrenergic signaling in cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Review
- Murine hematopoietic stem cells and progenitors express adrenergic receptors.Journal of neuroimmunology · 2007Article
- Bone marrow norepinephrine mediates development of functionally different macrophages after thermal injury and sepsis.Annals of surgery · 2004Article
- Thermal injury increases the number of eosinophil progenitors in rat spleen and bone marrow.Inflammation · 2001Article
- Propranolol restores the tumor necrosis factor-alpha response of circulating inflammatory monocytes and granulocytes after burn injury and sepsis.Journal of burn care & research : official publication of the American Burn AssociationArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether thermal injury and sepsis cause an increase in bone marrow norepinephrine release and whether such a release influences bone marrow monocytopoiesis. SUMMARY BACKGROUND DATA: The authors previously demonstrated enhanced bone marrow monocytopoiesis after burn with sepsis. They also showed that physiologic stress and bacterial challenge without injury could lead to a dynamic release of norepinephrine from the bone marrow compartment. In this study, they sought to determine the potential cause-and-effect relationship of bone marrow norepinephrine release on increased monocytopoiesis after burn sepsis.
methodsNorepinephrine release from bone marrow was determined by traditional pulse-chase methods. Tissue and bone marrow norepinephrine content was ablated by chemical sympathectomy with 6-hydroxydopamine treatment. Clonogenic potential in response to colony-stimulating factors was determined in total nucleated bone marrow cells. Dual color flow cytometry was used to document the distribution pattern of monocyte progenitors.
resultsBurn sepsis induced increased norepinephrine release in bone marrow, spleen, and heart. Colony-forming assays demonstrated an increase in responsive colonies, which was significantly attenuated when norepinephrine content was reduced in animals before burn sepsis. Flow cytometric analysis of early and late monocyte progenitors showed a significantly altered distribution profile of monocyte progenitors in norepinephrine-depleted mice compared with norepinephrine-intact mice. Abrogation of bone marrow norepinephrine content resulted in a 62% survival rate in burn septic mice compared with no survivors in norepinephrine-intact mice.
conclusionsThese data suggest that enhanced bone marrow norepinephrine release after burn sepsis may play a role in bone marrow monocytopoiesis, thus contributing to the sustenance of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.