ArticleAnnals of surgery2001
Surgical maneuvers enhance molecular detection of circulating tumor cells during gastric cancer surgery.
Article in Annals of surgery, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Meta-analysis shows that circulating tumor cells including circulating microRNAs are useful to predict the survival of patients with gastric cancer.BMC cancer · 2014Pooled it
- Circulating tumor cells (CTCs) detected by RT-PCR and its prognostic role in gastric cancer: a meta-analysis of published literature.PloS one · 2014Pooled it
- The effects of preoperative chemotherapy on isolated tumour cells in the blood and bone marrow of gastric cancer patients.British journal of cancer · 2007Trial
- Article
- Prognostic and predictive blood biomarkers in gastric cancer and the potential application of circulating tumor cells.World journal of gastroenterology · 2018Review
- Pathway of peritoneal carcinomatosis maybe hematogenous metastasis rather than peritoneal seeding.Oncotarget · 2017Article
- Clinical significance of circulating tumor cells in blood from patients with gastric cancer.Annals of gastroenterological surgery · 2017Review
- Clinical applications of liquid biopsies in gastrointestinal oncology.Journal of gastrointestinal oncology · 2016Review
- Detection and cultivation of circulating tumor cells in gastric cancer.Cytotechnology · 2016Article
- Evaluation of epithelial-mesenchymal transitioned circulating tumor cells in patients with resectable gastric cancer: Relevance to therapy response.World journal of gastroenterology · 2015Article
- Liquid biopsy of gastric cancer patients: circulating tumor cells and cell-free nucleic acids.World journal of gastroenterology · 2014Review
- Article
- Basic techniques in endoscopic ultrasound-guided fine needle aspiration for solid lesions: Adverse events and avoiding them.Endoscopic ultrasound · 2014Review
- Circulating tumor cells measurements in hepatocellular carcinoma.International journal of hepatology · 2012Article
- Identification of novel molecular markers for detection of gastric cancer cells in the peripheral blood circulation using genome-wide microarray analysis.Experimental and therapeutic medicine · 2011Article
- Detection of carcinoembryonic antigen messenger RNA in blood using quantitative real-time reverse transcriptase-polymerase chain reaction to predict recurrence of gastric adenocarcinoma.Journal of translational medicine · 2010Article
- Circulating tumor cells in gastrointestinal malignancies: current techniques and clinical implications.Journal of oncology · 2010Article
- Revisiting perioperative chemotherapy: the critical importance of targeting residual cancer prior to wound healing.BMC cancer · 2009Article
- Detection and clinical implications of minimal residual disease in gastro-intestinal cancer.Langenbeck's archives of surgery · 2005Review
- Enhancing antitumor immunity perioperatively: a matter of timing, cooperation, and specificity.American journal of respiratory cell and molecular biology · 2003Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the relation between the presence of cancer cells in blood according to the time course during a surgical procedure and liver metastases in patients with gastric cancer. SUMMARY BACKGROUND DATA: Several studies have reported on the detection of circulating cancer cells in blood by reverse transcriptase-polymerase chain reaction (RT-PCR). However, few reports have examined the relation between molecular detection of circulating cancer cells according to the time course during a surgical procedure and blood-borne metastases.
methodsBlood samples from 57 patients with gastric cancer were obtained from the portal vein, peripheral artery, and superior vena cava before and after tumor dissection. After total RNA was extracted from each blood sample, carcinoembryonic antigen (CEA)-specific RT-PCR was performed.
resultsCEA-mRNA was detected in the blood of 21 (36.8%) of the 57 patients. CEA-mRNA was not detected in the blood obtained from 15 healthy volunteers and 15 patients with benign disease. The positive rate increased in proportion to the depth of tumor. The incidence of positive CEA-mRNA did not differ among the various sites of blood sampling. The appearance of circulating cancer cells was related to the surgical maneuver. A significant relation was found between the detection of CEA-mRNA and blood-borne metastases.
conclusionsA high incidence of positive CEA-mRNA was found in the blood during gastric cancer surgery. Surgical maneuvers are a possible cause of hematogenous metastasis. The authors found that patients with positive CEA-mRNA had a high risk of blood-borne metastasis even after curative resection.
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