ArticleOncogene2000
Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrest.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 64 citations in OpenAlex.
- The Role of Gasotransmitter-Dependent Signaling Mechanisms in Apoptotic Cell Death in Cardiovascular, Rheumatic, Kidney, and Neurodegenerative Diseases and Mental Disorders.International journal of molecular sciences · 2023Review
- NO-Dependent Mechanisms of p53 Expression and Cell Death in Rat's Dorsal Root Ganglia after Sciatic-Nerve Transection.Biomedicines · 2022Article
- M1 macrophage dependent-p53 regulates the intracellular survival of mycobacteria.Apoptosis : an international journal on programmed cell death · 2020Article
- Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures.Oxidative medicine and cellular longevity · 2015Article
- Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.Cancer letters · 2015Review
- Trp53 deficiency protects against acute intestinal inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- S-nitrosylation in the regulation of gene transcription.Biochimica et biophysica acta · 2012Article
- Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation.The Journal of biological chemistry · 2010Article
- Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells.BMC cancer · 2009Article
- Regulation of heme oxygenase-1 mRNA deadenylation and turnover in NIH3T3 cells by nitrosative or alkylation stress.BMC molecular biology · 2007Article
- Nitric oxide is a physiological inhibitor of neurogenesis in the adult mouse subventricular zone and olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Article
- Regulation of neuronal proliferation and differentiation by nitric oxide.Molecular neurobiology · 2003Review
- Nitric oxide-induced cellular stress and p53 activation in chronic inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Site-specific and temporally-regulated retinoblastoma protein dephosphorylation by protein phosphatase type 1.Oncogene · 2001Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is an efficient inhibitor of cell proliferation. Here we show that part of the antiproliferative activity of NO in fibroblasts is mediated through p53 signaling pathway. Cells from p53-/- knockout mice are compromised in their ability to stop dividing in the presence of NO. NO strongly induces expression of genes which are transcriptional targets of p53, and p53 is necessary for some, but not all, of the transcription activation effects of NO. Furthermore, NO strongly increases the cellular level of p53 protein. Since phosphorylation of particular residues of the p53 molecule has been correlated with its functional activity, we determined the phosphorylation pattern of p53 molecule after exposure to NO and compared it with the phosphorylation patterns that develop upon treatment with gamma-irradiation, UV light, and adriamycin. We found that NO induces a specific signature pattern of p53 phosphorylation, distinct from the patterns evoked by other inducers. This study suggests that NO activates specific signaling pathways that may partially overlap, but that do not coincide, with signaling pathways activated by other known inducers of p53 activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.