ArticleOncogene2000
NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 94 citations in OpenAlex.
- Nitric oxide regulation of fetal and newborn lung development and function.Nitric oxide : biology and chemistry · 2024Review
- Deciphering the Role of Peroxisome Proliferator-activated Receptor α and Phosphodiesterase Type 5 Targets in Alzheimer's Disease.CNS & neurological disorders drug targets · 2024Review
- Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning.International journal of molecular sciences · 2023Article
- The Interplay between cGMP and Calcium Signaling in Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of PhosphofructokinaseFrontiers in cell and developmental biology · 2021Article
- Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing.JCI insight · 2020Article
- Protein Kinases in the Photic Signaling of the Mammalian Circadian Clock.The Yale journal of biology and medicine · 2019Review
- Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells.Scientific reports · 2018Article
- Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling.Oncotarget · 2017Article
- The Golgi apparatus regulates cGMP-dependent protein kinase I compartmentation and proteolysis.American journal of physiology. Cell physiology · 2015Article
- Synaptic therapy in Alzheimer's disease: a CREB-centric approach.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2015Review
- cGMP-dependent protein kinase I gamma encodes a nuclear localization signal that regulates nuclear compartmentation and function.Cellular signalling · 2014Article
- Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early genes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Transcriptional and post-transcriptional regulation of cGMP-dependent protein kinase (PKG-I): pathophysiological significance.Cardiovascular research · 2013Review
- Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene.Nitric oxide : biology and chemistry · 2011Article
- Nitric oxidergic cells related to ejaculation in gerbil forebrain contain androgen receptor and respond to testosterone.The Journal of comparative neurology · 2011Article
- Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity.The EMBO journal · 2009Article
- Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction.The Journal of biological chemistry · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We have shown that nitric oxide (NO) regulates c-fos gene expression via cGMP-dependent protein kinase (G-kinase), but NO's precise mechanism of action is unclear. We now demonstrate that: (1) NO targets two transcriptional elements in the fos promoter, i.e., the fos AP-1 binding site and the cAMP-response element (CRE); (2) NO activation of these two enhancer elements requires the CRE binding protein CREB because a dominant negative CREB fully inhibits NO transactivation of reporter genes whereas dominant negative Fos or CCAAT enhancer binding proteins have no effect; (3) CREB is phosphorylated by G-kinase in vitro and its phosphorylation increases in vivo when G-kinase is activated either directly by cGMP or indirectly by NO via soluble guanylate cyclase; (4) NO activation of fos promoter elements requires nuclear translocation of G-kinase but not activation of mitogen-activated protein kinases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.