ArticlePathology oncology research : POR1997
Immunohistochemical Characterization of Antioxidant Enzymes in Human Breast Cancer.
Article in Pathology oncology research : POR, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Catalase: The golden key to regulate oxidative stress in breast cancer.World journal of clinical oncology · 2025Review
- The role of ROS in tumour development and progression.Nature reviews. Cancer · 2022Review
- Article
- Expression of Mn-Superoxide Dismutase Gene in Nontumorigenic and Tumorigenic Human Mammary Epithelial Cells.Journal of biomedicine & biotechnology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrinsic antioxidant enzymes (AE) are essential for protection against potential cellular damage by free radicals (FRs), which affect a variety of biological processes. The levels or activities of AEs can be abnormal in human malignancies in general, and FR production is a possible mechanism of estrogen related carcinogenesis specifically. However, the role of AEs in breast cancer ramains unclear. Immunodetectable AEs were characterized in 95 node negative cancers using rabbit polyclonal antibodies. Results were correlated with established and experimental biomarkers of breast cancer. AEs were greater than benign differentiated epithelium in more than 40% and lower in 10-14% of tumors. Patterns of staining were enzyme and tumor pattern specific. Increased immunodetectable AE was associated with large, poorly differentiated tumors, and younger age. Catalase correlated with nuclear grade and disease related death (p< 0.05), and highlighted tumor microvasculature. Additional work in this area may further elucidate the role of AEs in breast cancer growth and progression.
Identifiers
11173648What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.