ArticleProceedings of the National Academy of Sciences of the United States of America2001
Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.
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131 citing papers in PubMed, 562 citations in OpenAlex.
- Cross-generational plasticity in Atlantic silversides (Menidia menidia) under the combined effects of hypoxia and acidification.The Journal of experimental biology · 2025Article
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- Mechanism of acclimation to chronic intermittent hypoxia in the gills of largemouth bass (Micropterus salmoides).Fish physiology and biochemistry · 2025Article
- The hypoxia response pathway in the Antarctic fish Notothenia coriiceps is functional despite a poly Q/E insertion mutation in HIF-1α.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2024Article
- Integrated Transcriptomics and Metabolomics Reveal Changes in Cell Homeostasis and Energy Metabolism inInternational journal of molecular sciences · 2024Article
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- Hypoxia-induced oxidative stress and apoptosis in gills of scaleless carp (Gymnocypris przewalskii).Fish physiology and biochemistry · 2022Article
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- Rainbow trout integrated response after recovery from short-term acute hypoxia.Frontiers in physiology · 2022Article
- Histopathological, hematological, and biochemical changes in high-latitude fish Phoxinus lagowskii exposed to hypoxia.Fish physiology and biochemistry · 2021Article
- The Atlantic salmon's stress- and immune-related transcriptional responses to moderate hypoxia, an incremental temperature increase, and these challenges combined.G3 (Bethesda, Md.) · 2021Article
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- The development of the OJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Targeting the Mild-Hypoxia Driving Force for Metabolic and Muscle Transcriptional Reprogramming of Gilthead Sea Bream (Biology · 2021Article
- The transcriptomic responses of Atlantic salmon (Salmo salar) to high temperature stress alone, and in combination with moderate hypoxia.BMC genomics · 2021Article
- Insights into early ontogenesis: characterization of stress and development key genes of pikeperch (Sander lucioperca) in vivo and in vitro.Fish physiology and biochemistry · 2021Article
- Transcriptional frontloading contributes to cross-tolerance between stressors.Evolutionary applications · 2021Article
- Differential sensitivity to warming and hypoxia during development and long-term effects of developmental exposure in early life stage Chinook salmon.Conservation physiology · 2021Article
71 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia is important in both biomedical and environmental contexts and necessitates rapid adaptive changes in metabolic organization. Mammals, as air breathers, have a limited capacity to withstand sustained exposure to hypoxia. By contrast, some aquatic animals, such as certain fishes, are routinely exposed and resistant to severe environmental hypoxia. Understanding the changes in gene expression in fishes exposed to hypoxic stress could reveal novel mechanisms of tolerance that may shed new light on hypoxia and ischemia in higher vertebrates. Using cDNA microarrays, we have studied gene expression in a hypoxia-tolerant burrow-dwelling goby fish, Gillichthys mirabilis. We show that a coherent picture of a complex transcriptional response can be generated for a nonmodel organism for which sequence data were unavailable. We demonstrate that: (i) although certain shifts in gene expression mirror changes in mammals, novel genes are differentially expressed in fish; and (ii) tissue-specific patterns of expression reflect the different metabolic roles of tissues during hypoxia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.