ArticleProceedings of the National Academy of Sciences of the United States of America2001
The role of zinc in the binding of killer cell Ig-like receptors to class I MHC proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Zinc deficiency as possible link between immunosenescence and age-related diseases.Immunity & ageing : I & A · 2025Review
- Group AScience immunology · 2023Article
- Review
- Effects of Peptide on NK cell-mediated MHC I recognition.Frontiers in immunology · 2014Review
- MHC class I dimer formation by alteration of the cellular redox environment and induction of apoptosis.Immunology · 2012Article
- Zinc in innate and adaptive tumor immunity.Journal of translational medicine · 2010Review
- The killer's kiss: the many functions of NK cell immunological synapses.Current opinion in cell biology · 2008Review
- Activation of NK cells by an endocytosed receptor for soluble HLA-G.PLoS biology · 2006Article
- Understanding how combinations of HLA and KIR genes influence disease.The Journal of experimental medicine · 2005Review
- Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells.The Journal of experimental medicine · 2003Article
- Disulfide bond-mediated dimerization of HLA-G on the cell surface.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Bovine leukemia virus SU protein interacts with zinc, and mutations within two interacting regions differently affect viral fusion and infectivity in vivo.Journal of virology · 2002Article
- Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc.Mediators of inflammation · 2002Article
- Signaling at the inhibitory natural killer cell immune synapse regulates lipid raft polarization but not class I MHC clustering.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Intercellular transfer and supramolecular organization of human leukocyte antigen C at inhibitory natural killer cell immune synapses.The Journal of experimental medicine · 2001Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The binding of killer cell Ig-like Receptors (KIR) to their Class I MHC ligands was shown previously to be characterized by extremely rapid association and dissociation rate constants. During experiments to investigate the biochemistry of receptor-ligand binding in more detail, the kinetic parameters of the interaction were observed to alter dramatically in the presence of Zn(2+) but not other divalent cations. The basis of this phenomenon is Zn(2+)-induced multimerization of the KIR molecules as demonstrated by BIAcore, analytical ultracentrifugation, and chemical cross-linking experiments. Zn(2+)-dependent multimerization of KIR may be critical for formation of the clusters of KIR and HLA-C molecules, the "natural killer (NK) cell immune synapse," observed at the site of contact between the NK cell and target cell.
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