ArticleProceedings of the National Academy of Sciences of the United States of America2001
Untargeted mutation of the maternally derived mouse hypervariable minisatellite allele in F1 mice born to irradiated spermatozoa.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- The repetitive DNA landscape in Avena (Poaceae): chromosome and genome evolution defined by major repeat classes in whole-genome sequence reads.BMC plant biology · 2019Article
- Radiation-Induced Bystander Response: Mechanism and Clinical Implications.Advances in wound care · 2014Review
- Sidestream tobacco smoke is a male germ cell mutagen.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Isolated spermatozoa as indicators of mutations transmitted to progeny.Mutation research · 2010Article
- Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2008Review
- Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Transgenerational accumulation of radiation damage in small mammals chronically exposed to Chernobyl fallout.Radiation and environmental biophysics · 2006Article
- Effects of ionizing radiation in nonirradiated cells.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Review
- Radiation-induced transgenerational instability.Oncogene · 2003Review
- Review
- Air pollution induces heritable DNA mutations.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm.Molecular and cellular biology · 2002Article
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Authors and funding
2 authors.
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Abstract
Length change mutation at the Ms6hm hypervariable mouse minisatellite locus was analyzed in C57BL/6N x C3H/HeN F(1) mice and the F(1) of the reciprocal cross born to irradiated male parents. Spontaneous mutant frequencies were 8.4% and 9.8% for the paternally derived and maternally derived C3H/HeN alleles, respectively. The mutant frequencies for the paternally derived allele increased to 22% and 19% when the male parents were irradiated with 6 Gy at the postmeiotic spermatozoa stage and the spermatogonia stage, respectively. These increases in the mutant frequency were at least 10 to 100 times higher than those expected from the frequency of hits to the 3- to 4-kb allele, suggesting that the length change mutation at this minisatellite locus was not a targeted event due directly to DNA damage in the region. Further analysis demonstrated that the mutant frequency increased also at the maternally derived C3H/HeN allele to 20% when the male parents were irradiated at the spermatozoa stage. This increase in the maternal allele mutation was not observed in F(1) born to irradiated spermatogonia. The present study suggests that introduction of DNA damage by irradiated sperm triggers genomic instability in zygotes and in embryos of subsequent developmental stages, and this genomic instability induces untargeted mutation in cis at the paternally derived minisatellite allele and in trans at the maternally derived unirradiated allele. Untargeted mutation revealed in the present study defines a previously unnoticed genetic hazard to the maternally derived genome by the paternally introduced DNA damage.
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