ArticleProceedings of the National Academy of Sciences of the United States of America2001
From cell death to embryo arrest: mathematical models of human preimplantation embryo development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An Updated Understanding of Human Embryonic Fragmentation.Reproductive sciences (Thousand Oaks, Calif.) · 2026Pooled it
- Evaluating the Impact of Female Factors on Specific Stages of Early Embryo Development: A Retrospective Analysis of 1372 IVF Cycles.International journal of women's health · 2026Article
- Non-Invasive Preimplantation Genetic Testing.Genes · 2025Review
- An aggregated mitochondrial distribution in preimplantation embryos disrupts nuclear morphology, function, and developmental potential.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells.World journal of stem cells · 2024Article
- Evolution of Minimally Invasive and Non-Invasive Preimplantation Genetic Testing: An Overview.Journal of clinical medicine · 2024Review
- Insights into embryonic chromosomal instability: mechanisms of DNA elimination during mammalian preimplantation development.Frontiers in cell and developmental biology · 2024Review
- The origin and possible mechanism of embryonic cell-free DNA release in spent embryo culture media: a review.Journal of assisted reproduction and genetics · 2023Review
- A developmentally programmed splicing failure contributes to DNA damage response attenuation during mammalian zygotic genome activation.Science advances · 2022Article
- Preimplantation chromosomal mosaics, chimaeras and confined placental mosaicism.Reproduction & fertility · 2022Review
- Disposition of embryos from women who only produced morphologically poor embryos on day three.Biomedical journal · 2022Observational
- Cellular and Molecular Nature of Fragmentation of Human Embryos.International journal of molecular sciences · 2022Review
- The impact of using culture media containing granulocyte-macrophage colony-stimulating factor on live birth rates in patients with a history of embryonic developmental arrest in previous in vitro fertilization cyclesJournal of the Turkish German Gynecological Association · 2021Article
- When embryology meets genetics: the definition of developmentally incompetent preimplantation embryos (DIPE)-the consensus of two Italian scientific societies.Journal of assisted reproduction and genetics · 2021Article
- PGE2 Supplementation of Oocyte Culture Media Improves the Developmental and Cryotolerance Performance of Bovine Blastocysts Derived From a Serum-FreeFrontiers in cell and developmental biology · 2021Article
- Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice.eLife · 2020Article
- Preimplantation loss of fertilized human ova: estimating the unobservable.Human reproduction (Oxford, England) · 2020Article
- Single-cell sequencing of primate preimplantation embryos reveals chromosome elimination via cellular fragmentation and blastomere exclusion.Genome research · 2019Article
- Article
- A model for postzygotic mosaicisms quantifies the allele fraction drift, mutation rate, and contribution to de novo mutations.Genome research · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human preimplantation embryos exhibit high levels of apoptotic cells and high rates of developmental arrest during the first week in vitro. The relation between the two is unclear and difficult to determine by conventional experimental approaches, partly because of limited numbers of embryos. We apply a mixture of experiment and mathematical modeling to show that observed levels of cell death can be reconciled with the high levels of embryo arrest seen in the human only if the developmental competence of embryos is already established at the zygote stage, and environmental factors merely modulate this. This suggests that research on improving in vitro fertilization success rates should move from its current concentration on optimizing culture media to focus more on the generation of a healthy zygote and on understanding the mechanisms that cause chromosomal and other abnormalities during early cleavage stages.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.