ArticleProceedings of the National Academy of Sciences of the United States of America2001
Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 beta.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A resource for integrated genomic analysis of the human liver.Scientific reports · 2022Pooled it
- Human Synthetic Biology and Programmable Gene Regulation Control.Annual review of genomics and human genetics · 2025Review
- Gene regulatory network analysis identifies MYL1, MDH2, GLS, and TRIM28 as the principal proteins in the response of mesenchymal stem cells to MgComputational and structural biotechnology journal · 2024Article
- Mapping the interaction between Trim28 and the KRAB domain at the center of Trim28 silencing of endogenous retroviruses.Protein science : a publication of the Protein Society · 2022Article
- Expression pattern of ZNF33B in bovine ovaries and the effect of its polymorphism on superovulation traits.Archives animal breeding · 2022Article
- Gene Editing to Tackle Facioscapulohumeral Muscular Dystrophy.Frontiers in genome editing · 2022Review
- RIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment.Molecular cancer · 2021Article
- Expression of ZNF695 Transcript Variants in Childhood B-Cell Acute Lymphoblastic Leukemia.Genes · 2019Article
- Endogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis.Oncogene · 2018Article
- Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor.Scientific reports · 2017Article
- Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice.Molecular neurodegeneration · 2016Article
- Genes and Conditions Controlling Mammalian Pre- and Post-implantation Embryo Development.Current genomics · 2015Article
- Chromatin regulators of genomic imprinting.Biochimica et biophysica acta · 2014Review
- Article
- KAP1 regulates gene networks controlling T-cell development and responsiveness.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Heterogeneity of molecular markers in chronic myelomonocytic leukemia: a disease associated with several gene alterations.Cellular and molecular life sciences : CMLS · 2012Review
- ZNF764 haploinsufficiency may explain partial glucocorticoid, androgen, and thyroid hormone resistance associated with 16p11.2 microdeletion.The Journal of clinical endocrinology and metabolism · 2012Article
- A role for CARM1-mediated histone H3 arginine methylation in protecting histone acetylation by releasing corepressors from chromatin.PloS one · 2012Article
- TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues.Development (Cambridge, England) · 2011Article
- Mammalian genomic imprinting.Cold Spring Harbor perspectives in biology · 2011Review
Corrections and comments
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The Krüppel-associated box (KRAB) domain, originally identified as a 75-aa sequence present in numerous Krüppel-type zinc-finger proteins, is a potent DNA-binding-dependent transcriptional repression domain that is believed to function through interaction with the transcriptional intermediary factor 1 (TIF1) beta. On the basis of sequence comparison and phylogenetic analysis, we have recently defined three distinct subfamilies of KRAB domains. In the present study, individual members of each subfamily were tested for transcriptional repression and interaction with TIF1 beta and two other closely related family members (TIF1 alpha and TIF1 gamma). All KRAB variants were shown, (i) to repress transcription when targeted to DNA through fusion to a heterologous DNA-binding domain in mammalian cells, and (ii) to interact specifically with TIF1 beta, but not with TIF1 alpha or TIF1 gamma. Taken together, these results implicate TIF1 beta as a common transcriptional corepressor for the three distinct subfamilies of KRAB zinc-finger proteins and suggest a high degree of conservation in the molecular mechanism underlying their transcriptional repression activity.
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