ArticleThe Biochemical journal2001
Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII).
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells.bioRxiv : the preprint server for biology · 2026Article
- Proper Frequency of Perinatal Retinal Waves Is Essential for the Precise Wiring of Visual Axons in Nonimage-Forming Nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Heterozygous knockout of Synaptotagmin13 phenocopies ALS features and TP53 activation in human motor neurons.Cell death & disease · 2024Article
- Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis.Nature communications · 2022Article
- Synaptotagmin 13 is neuroprotective across motor neuron diseases.Acta neuropathologica · 2020Article
- Silencing of synaptotagmin 13 inhibits tumor growth through suppressing proliferation and promoting apoptosis of colorectal cancer cells.International journal of molecular medicine · 2020Article
- The levels of SYT13 and CEA mRNAs in peritoneal lavages predict the peritoneal recurrence of gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019Article
- Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants.BMC neuroscience · 2007Article
- Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis.BMC genomics · 2007Article
- Synaptotagmin gene content of the sequenced genomes.BMC genomics · 2004Article
- Comparative analysis of tandem C2 domains from the mammalian synaptotagmin family.The Biochemical journal · 2004Article
- The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I.The Biochemical journal · 2002Article
- Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human.The Biochemical journal · 2002Article
- The N-terminal cysteine cluster is essential for membrane targeting of B/K protein.The Biochemical journal · 2001Article
- The AP2 binding site of synaptotagmin 1 is not an internalization signal but a regulator of endocytosis.The Journal of cell biology · 2001Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptotagmin (Syt) belongs to a family of type-I membrane proteins and is a protein that consists of a short extracellular N-terminus, a single transmembrane domain, two C2 domains and a short C-terminus. Here, we cloned and characterized a mouse orthologue of human KIAA1427 protein as an atypical Syt (named Syt XIII). Subcellular fractionation and antibody-uptake experiments indicate that Syt XIII is indeed a type-I membrane protein, but, unlike other Syt isoforms, lacks an N-terminal extracellular domain. Syt XIII C2 domains show relatively little similarity to Syt I (less than 35% identity at the amino acid level), and lack key amino acids responsible for Ca2+ binding. Because of these substitutions, the Syt XIII C2 domains did not show Ca2+-dependent phospholipid-binding activity, and Syt XIII is thus classified as a Ca2+ -independent isoform. By contrast, the Syt XIII C-terminal domain is highly homologous with other Syt isoforms and can function as a common receptor for neurexin Ialpha in vitro. Since Syt XIII is expressed in various tissues outside the brain, Syt XIII may be involved in constitutive vesicle transport.
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