ArticleThe Biochemical journal2001
Identification of synapsin I peptides that insert into lipid membranes.
Article in The Biochemical journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Dynamic regulation of vesicle pools in a detailed spatial model of the complete synaptic vesicle cycle.Science advances · 2025Article
- Morphology and intervesicle distances in condensates of synaptic vesicles and synapsin.Biophysical journal · 2024Article
- Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles.Nature communications · 2024Article
- Vesicle condensation induced by synapsin: condensate size, geometry, and vesicle shape deformations.The European physical journal. E, Soft matter · 2024Article
- Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons.Cell death & disease · 2022Article
- Review
- Phase separation at the synapse.Nature neuroscience · 2020Review
- Heroin Cue-Evoked Astrocytic Structural Plasticity at Nucleus Accumbens Synapses Inhibits Heroin Seeking.Biological psychiatry · 2019Article
- SIV-Mediated Synaptic Dysfunction Is Associated with an Increase in Synapsin Site 1 Phosphorylation and Impaired PP2A Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Epitope specificity of anti-synapsin autoantibodies: Differential targeting of synapsin I domains.PloS one · 2018Article
- Synapsin Isoforms Regulating GABA Release from Hippocampal Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Synapsin Isoforms and Synaptic Vesicle Trafficking.Molecules and cells · 2015Review
- Functional role of ATP binding to synapsin I in synaptic vesicle trafficking and release dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Fast vesicle transport is required for the slow axonal transport of synapsin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
- Article
- Sex steroid hormones regulate the expression of growth-associated protein 43, microtubule-associated protein 2, synapsin 1 and actin in the ventromedial nucleus of the hypothalamus.Journal of molecular neuroscience : MN · 2012Article
- Influence of synapsin I on synaptic vesicles: an analysis by force-volume mode of the atomic force microscope and dynamic light scattering.Biophysical journal · 2007Article
- The role of hydrophobic interactions in positioning of peripheral proteins in membranes.BMC structural biology · 2007Article
- Structural domains involved in the regulation of transmitter release by synapsins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The synapsins constitute a family of synaptic vesicle-associated phosphoproteins essential for regulating neurotransmitter release and synaptogenesis. The molecular mechanisms underlying the selective targeting of synapsin I to synaptic vesicles are thought to involve specific protein-protein interactions, while the high-affinity binding to the synaptic vesicle membrane may involve both protein-protein and protein-lipid interactions. The highly hydrophobic N-terminal region of the protein has been shown to bind with high affinity to the acidic phospholipids phosphatidylserine and phosphatidylinositol and to penetrate the hydrophobic core of the lipid bilayer. To precisely identify the domains of synapsin I which mediate the interaction with lipids, synapsin I was bound to liposomes containing the membrane-directed carbene-generating reagent 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine and subjected to photolysis. Isolation and N-terminal amino acid sequencing of 125I-labelled synapsin I peptides derived from CNBr cleavage indicated that three distinct regions in the highly conserved domain C of synapsin I insert into the hydrophobic core of the phospholipid bilayer. The boundaries of the regions encompass residues 166-192, 233-258 and 278-327 of bovine synapsin I. These regions are surface-exposed in the crystal structure of domain C of bovine synapsin I and are evolutionarily conserved among isoforms across species. The present data offer a molecular explanation for the high-affinity binding of synapsin I to phospholipid bilayers and synaptic vesicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.