ArticleInternational journal of experimental pathology2000
Collagen metabolism disturbances are accompanied by an increase in prolidase activity in lung carcinoma planoepitheliale.
Article in International journal of experimental pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- The Prolidase Activity, Oxidative Stress, and Nitric Oxide Levels of Bladder Tissues with or Without Tumor in Patients with Bladder Cancer.The Journal of membrane biology · 2017Trial
- ClearF++: Improved Supervised Feature Scoring Using Feature Clustering in Class-Wise Embedding and Reconstruction.Bioengineering (Basel, Switzerland) · 2023Article
- Metabolomics analysis of plasma samples of patients with fibromyalgia and electromagnetic sensitivity using GC-MS technique.Scientific reports · 2022Article
- NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells.International journal of molecular sciences · 2022Article
- Extracellular Prolidase (PEPD) Induces Anabolic Processes through EGFR, βInternational journal of molecular sciences · 2021Article
- PROLIDASE: A Review from Discovery to its Role in Health and Disease.Frontiers in molecular biosciences · 2021Review
- Oxidative Stress and Musculoskeletal Pain in University Students with Generalized Joint Hypermobility: A Case-Control Study.Journal of pain research · 2021Article
- A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor.Pharmacological reports : PR · 2020Review
- Current Understanding of the Emerging Role of Prolidase in Cellular Metabolism.International journal of molecular sciences · 2020Review
- Serum Prolidase Enzyme Activity Level: Not a Predictive Biomarker for Epilepsy.The Eurasian journal of medicine · 2019Article
- Comprehensive in-silico prediction of damage associated SNPs in Human Prolidase gene.Scientific reports · 2018Article
- Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol.Drug design, development and therapy · 2017Article
- Prolidase Enzyme Activity in Conjunctiva and Pterygium Tissues.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma.World journal of gastroenterology · 2015Article
- Enalapril stimulates collagen biosynthesis through prolidase-dependent mechanism in cultured fibroblasts.Naunyn-Schmiedeberg's archives of pharmacology · 2015Article
- Prolidase activity in chronic plaque psoriasis patients.Postepy dermatologii i alergologii · 2015Article
- Serum prolidase enzyme activity and oxidative status in patients with fibromyalgia.Redox report : communications in free radical research · 2014Article
- Factor-Xa inhibitors protect against systemic oxidant damage induced by peripheral-ischemia reperfusion.Journal of thrombosis and thrombolysis · 2014Article
- Serum prolidase enzyme activity and oxidative status in patients with Behçet's disease.Redox report : communications in free radical research · 2014Article
- Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the consequences of neoplastic transformation is deregulation of tissue collagen metabolism. Although metalloproteinases initiate the breakdown of collagen in lung carcinoma, the final step of collagen degradation is mediated by prolidase (E.C.3.4.13.9). We investigated whether prolidase activity could reflect disturbances of collagen metabolism in human lung carcinoma planoepitheliale (Ca pl.). Ten human lung Ca pl. and 10 samples of normal lung parenchyma were compared with respect to prolidase activity and expression (western immunoblot), the content of collagen and collagen degradation products (free and bound hydroxyproline determination), beta1 integrin subunit expression (western immunoblot) and collagenolytic activity (zymography). An increase in collagen content (66%, P < 0.05), free proline pool (50%, P < 0.05) and collagenolytic activity was accompanied by a significant increase in the prolidase activity (106%, P < 0.05) and its expression in Ca pl. No differences were found between Ca pl. and the control lung tissue with respect to beta1 integrin expression. Prolidase activity may reflect disturbances in tissue collagen metabolism in lung Ca pl. and it may, therefore, serve as a sensitive marker of the disease.
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